Evidence map›Paper›PMID 35596548›Full record

ArticleChirality2022

Resolution via diastereomeric amides of enantiopure 1,4-benzoxathian-2- and 3-carboxylic acids and determination of their configuration.

Valentina Straniero, Giulia Lodigiani, Lorenzo Suigo, Ermanno Valoti

Abstract read
In one paragraph

Article in Chirality, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valentina StranieroDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-5089-0879
Giulia LodigianiDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-7369-7708
Lorenzo SuigoDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-8958-1547
Ermanno ValotiDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-5608-3875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,4-Benzoxathiane, 2- or 3-substituted, is an important scaffold, and despite its presence in several therapeutic agents, it is chemically unexploited. Furthermore, only a few examples in literature report this moiety in its enantiopure form. Here, taking advantage to the formation of diastereomeric amides by using (S)-phenylethylamine, which show significant differences in terms of

Indexed as

AmidesCarboxylic AcidsMagnetic Resonance SpectroscopyPhenethylaminesStereoisomerismAmidesCarboxylic AcidsPhenethylamines1,4-benzoxathiane-2-carboxamide1,4-benzoxathiane-3-carboxamide1H NMR comparisonabsolute configuration determinationchiral HPLCdiastereomeric amides(S)-phenylethylamine

Identifiers

PMID35596548
PMCPMC9541051

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.