ArticleBiophysical journal2022
Observation of broken detailed balance in polymorphic transformation of bacterial flagellar filament.
Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Identification and quantification of irreversibility in stochastic systems.Physical chemistry chemical physics : PCCP · 2026Review
- Decoding Bacterial Motility: From Swimming States to Patterns and Chemotactic Strategies.Biomolecules · 2025Review
- Flagellar motors of swimming bacteria contain an incomplete set of stator units to ensure robust motility.Science advances · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Living systems operate far from thermodynamic equilibrium, which usually manifests as broken detailed balance at the molecular scale. At larger scales with collective function of many molecules, the presence of non-equilibrium thermodynamics may not be evident. In bacterial motility, the switching dynamics of the flagellar rotary motor was recently discovered to be operating in non-equilibrium. However, the resulting motility pattern at the mesoscale, the run-and-tumble behavior, was normally considered to be a Poisson process that can be described by a two-state equilibrium model. Here, we studied the details of the run-and-tumble behavior by following the polymorphic transformation of the flagellar filaments, observing broken detailed balance that reveals its non-equilibrium nature. Evaluation of entropy production provided a direct measure of the lack of detailed balance and a quantification of the rate of energy dissipation for bacterial run-and-tumble regulation.
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