ArticleBMC complementary medicine and therapies2022
Chemical composition, antibiofilm, cytotoxic, and anti-acetylcholinesterase activities of Myrtus communis L. leaves essential oil.
Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Chemical Characterization, Evaluation of Antimicrobial Potential, and Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2026Article
- Decoding Ocimum basilicum L.'s Medicinal Potential Through Growth Phase Profiling: A Conservation Perspective.Chemistry & biodiversity · 2026Article
- Optimization of TunisianMetabolites · 2025Article
- Comprehensive In Vitro and In Silico Analysis of Antimicrobial and Insecticidal Properties of Essential Oil ofInternational journal of molecular sciences · 2025Article
- Essential Oils for Biofilm Control: Mechanisms, Synergies, and Translational Challenges in the Era of Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Article
- Review
- Antibacterial activity ofFrontiers in plant science · 2025Article
- Antimycobacterial and Anticancer Properties ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Natural compounds in the fight againstFrontiers in pharmacology · 2024Review
- Kaempferol restores the susceptibility of ESBLsFrontiers in microbiology · 2024Article
- Chemical Composition, Antibacterial Properties, and Anti-Enzymatic Effects ofMolecules (Basel, Switzerland) · 2023Article
- Unveiling the Chemical Profiling Antioxidant and Anti-Inflammatory Activities of AlgerianPharmaceuticals (Basel, Switzerland) · 2023Article
- Antimicrobial Effects and Antioxidant Activity ofFoods (Basel, Switzerland) · 2023Article
- Mediterranean Plants with Antimicrobial Activity againstMicroorganisms · 2023Article
- Antibacterial and Antibiofilm Effects of Different Samples of Five Commercially Available Essential Oils.Antibiotics (Basel, Switzerland) · 2023Article
- Flowering phenophases influence the antibacterial and anti-biofilm effects of Thymus vulgaris L. essential oil.BMC complementary medicine and therapies · 2023Article
- The Leaf Essential Oil ofPlants (Basel, Switzerland) · 2023Article
- Inhibitory Effect of Sodium Alginate Nanoemulsion Coating Containing Myrtle Essential Oil (Molecules (Basel, Switzerland) · 2022Article
- An Overview of Biofilm Formation-Combating Strategies and Mechanisms of Action of Antibiofilm Agents.Life (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe potential of essential oils (EOs) and of their principal constituents for eradication of biofilm and at the same time the research of new potential acetylcholinesterase inhibitors is gaining increasing interest in last years. The aims of this study were to determine the chemical composition and to evaluate the antibacterial, cytotoxic, and anti-acetylcholinesterase properties of Myrtus communis leaves essential oil and its main constituents.
methodsEssential oil was obtained by hydrodistillation of M. communis L. leaves and was analyzed by GC and GC-MS. The antimicrobial activity was carried out against both gram-negative and gram-positive bacteria. The microdilution method was used to estimate the minimum inhibitory concentrations (MICs). Then, the capacity of essential oil and its main constituent to inhibit biofilm growth, with the method of O'Toole and Kolterand, and the metabolic activity of biofilm cells through the MTT colorimetric method were evaluated at different times. Moreover, was studied the potential cytotoxic activity against SH-SY5Y cell line with MTT assay and the anti-acetylcholinesterase activity using Ellman's assay.
resultsMyrtenyl-acetate, 1,8 cineole, α-pinene, and linalool were the main components in the EO. The myrtle EO, at the minimum tested dose (0.4 mg/ml), inhibited S. aureus biofilm by 42.1% and was capable of inhibiting the biofilm cell metabolism in all tested strains, except Staphylococcus aureus. Moreover, the EO showed good cytotoxic and anti-acetylcholinesterase activities IC
conclusionsThe results suggest that myrtle EO and its main constituents could be used as possible products that could act against the resistant pathogenic species E. coli, P. aeruginosa, L. monocytogenes and S. aureus, on the other hand, as possible coadjutants in the treatment of neurological diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.