Evidence map›Paper›PMID 35596108›Full record

ReviewTherapeutic innovation & regulatory science2022

Health Equity in Pediatric Drug Development: Translating Aspiration into Operation.

Morenike Oluwatoyin Folayan, Magda Conway, Carolyn Russo, Nilza Diniz, Lungile P Jafta, Nadia A Sam-Agudu, Sarah Bernays, Victor M Santana, Carla Epps, Mark A Turner

Abstract readReview
In one paragraph

Review in Therapeutic innovation & regulatory science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Morenike Oluwatoyin FolayanDepartment of Child Dental Health, Obafemi Awolowo University, Ile-Ife, Nigeria.
Magda ConwayPENTA, Corso Stati Uniti 4, 35127, Padua, Italy.
Carolyn RussoDepartment of Hematology, St. Jude Children's Research Hospital and Comprehensive Cancer Center, Memphis, TN, USA.
Nilza DinizBiology Department, Biological Sciences Center, State University of Londrina, Londrina, PR, 86057-970, Brazil.
Lungile P JaftaPENTA, Corso Stati Uniti 4, 35127, Padua, Italy.
Nadia A Sam-AguduInternational Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria.
Sarah BernaysSchool of Public Health, University of Sydney, Sydney, Australia.
Victor M SantanaDepartments of Oncology and Global Pediatric Medicine, St. Jude Children's Research Hospital and Comprehensive Cancer Center, Memphis, TN, USA.
Carla EppsOffice of Pediatric Therapeutics, Food and Drug Administration, Silver Spring, MD, USA.
Mark A TurnerInstitute of Life Course and Medical Sciences, University of Liverpool, Liverpool Health Partners, Liverpool, UK. Mark.Turner@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-5299-8656

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

The concept of health equity-the attainment of the highest possible level of health for all members of society-requires equitable access to all aspects of healthcare, including pediatric drug development. However, many communities are under-represented in pediatric drug development programs. Barriers to participation include geographic, economic, racial/ethnic bias, legal, cultural, linguistic, and other factors. While there is no "one size fits all" approach to addressing these barriers, community engagement and collaboration is recognized by the Centers for Disease Control, the World Health Organization, and other global health organizations as a cornerstone for building a more equitable healthcare system. In this article, we will present case studies of stakeholder and community engagement in clinical research for rare diseases and other areas of healthcare, as examples of strategies and practices for actively involving under-represented communities and fostering their participation in pediatric drug development programs. These studies may serve as templates for facilitating equity in pediatric drug development from aspiration into operation.

Indexed as

Drug DevelopmentHealth EquityPediatricsChildHumansAccessAdolescentChildDrug developmentEngagementHealth equityStakeholders

Identifiers

PMID35596108
PMCPMC9122543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.