Evidence map›Paper›PMID 35595876›Full record

ArticleScientific reports2022

Murine cardiac fibrosis localization using adaptive Bayesian cardiac strain imaging in vivo.

Rashid Al Mukaddim, Ashley M Weichmann, Rachel Taylor, Timothy A Hacker, Thomas Pier, Joseph Hardin, Melissa Graham, Carol C Mitchell, Tomy Varghese

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Lagrangian deformation tracking for strain imaging.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rashid Al MukaddimMedical Physics, University of Wisconsin (UW)-Madison, Madison, USA. mukaddim@wisc.edu.
Ashley M WeichmannSmall Animal Imaging and Radiotherapy Facility, UW-Madison, Madison, USA.
Rachel TaylorCardiovascular Physiology Core Facility, UW-Madison, Madison, USA.
Timothy A HackerCardiovascular Physiology Core Facility, UW-Madison, Madison, USA.
Thomas PierExperimental Animal Pathology Lab, UW-Madison, Madison, USA.
Joseph HardinExperimental Animal Pathology Lab, UW-Madison, Madison, USA.
Melissa GrahamComparative Pathology Laboratory, Research Animal Resources and Compliance (RARC), UW-Madison, Madison, USA.
Carol C MitchellMedicine/Division of Cardiovascular Medicine, UW-Madison, Madison, USA.
Tomy VargheseMedical Physics, University of Wisconsin (UW)-Madison, Madison, USA. tvarghese@wisc.edu.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingR01HL147866 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2020 to 2023
$2.9M
Ultrasonic and Photoacoustic Imaging System for Cancer & Cardiovascular ResearchS10OD018505 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2015 to 2015
$908k
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL147866NIH HHS 1R01HL147866-01NIH HHS S10 OD018505
6 · The paper itself

Abstract

An adaptive Bayesian regularized cardiac strain imaging (ABR-CSI) algorithm for in vivo murine myocardial function assessment is presented. We report on 31 BALB/CJ mice (n = 17 females, n = 14 males), randomly stratified into three surgical groups: myocardial infarction (MI, n = 10), ischemia-reperfusion (IR, n = 13) and control (sham, n = 8) imaged pre-surgery (baseline- BL), and 1, 2, 7 and 14 days post-surgery using a high frequency ultrasound imaging system (Vevo 2100). End-systole (ES) radial and longitudinal strain images were used to generate cardiac fibrosis maps using binary thresholding. Percentage fibrotic myocardium (PFM) computed from regional fibrosis maps demonstrated statistically significant differences post-surgery in scar regions. For example, the MI group had significantly higher PFM

Indexed as

HeartMyocardial InfarctionAnimalsBayes TheoremDisease Models, AnimalFemaleFibrosisMaleMiceMyocardium

Identifiers

PMID35595876
PMCPMC9122999

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.