Evidence map›Paper›PMID 35595213›Full record

ArticleGenomics, proteomics & bioinformatics2023

RNA2Immune: A Database of Experimentally Supported Data Linking Non-coding RNA Regulation to The Immune System.

Jianjian Wang, Shuang Li, Tianfeng Wang, Si Xu, Xu Wang, Xiaotong Kong, Xiaoyu Lu, Huixue Zhang, Lifang Li, Meng Feng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. GIDISdb: a gene expression database for exploring human immune responses in infectious diseases.Database : the journal of biological databases and curation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jianjian WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Shuang LiDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Tianfeng WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Si XuDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Xu WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Xiaotong KongDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Xiaoyu LuDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Huixue ZhangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Lifang LiDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Meng FengDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Shangwei NingCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. Electronic address: ningsw@ems.hrbmu.edu.cn.
Lihua WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. Electronic address: H06844@hrbmu.edu.cn.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as important regulators of the immune system and are involved in the control of immune cell biology, disease pathogenesis, as well as vaccine responses. A repository of ncRNA-immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune disorders. Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune-ncRNA associations in 42 host species, including (1) 6690 ncRNA associations with immune functions involving 31 immune cell types; (2) 38,672 ncRNA associations with 348 immune diseases; (3) 4833 ncRNA associations with cancer immunology; and (4) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. RNA2Immune provides a user-friendly interface for browsing, searching, and downloading ncRNA-immune system associations. Collectively, RNA2Immune provides important information about how ncRNAs influence immune cell function, how dysregulation of these ncRNAs leads to pathological consequences (immune diseases and cancers), and how ncRNAs affect immune responses to vaccines. RNA2Immune is available at http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp.

Indexed as

Immune System DiseasesMicroRNAsNeoplasmsRNA, Long NoncodingVaccinesHumansImmune SystemRNA, UntranslatedMicroRNAsRNA, Long NoncodingRNA, UntranslatedVaccinesCancer immunologyImmune cellImmune diseasencRNAVaccine

Identifiers

PMID35595213
PMCPMC10626051
OpenAlexW4280568220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.