ArticleNature2022
Compatibility rules of human enhancer and promoter sequences.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
110 citing papers in PubMed, 160 citations in OpenAlex.
- ELF5-Mediated Enhancer-Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanisms and functional implications of long-range enhancer-dependent gene regulation.Nature genetics · 2026Review
- Article
- Mapping enhancer-gene regulatory interactions from single-cell data.Nature genetics · 2026Article
- Locus-Scale Massively Parallel Reporter Assays.bioRxiv : the preprint server for biology · 2026Article
- Using a modular massively parallel reporter assay to discover context-dependent regulatory activity in type 2 diabetes-linked noncoding regions.HGG advances · 2026Article
- The Encyclopedia of DNA Elements.bioRxiv : the preprint server for biology · 2026Article
- Distinct and compensatory roles of STAG1 and STAG2 in post-mitotic genome refolding.Nature communications · 2026Article
- Intrinsic promoter responsiveness dictates sensitivity to transcriptional activation by enhancers.bioRxiv : the preprint server for biology · 2026Article
- Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use.Genesis (New York, N.Y. : 2000) · 2026Article
- Refining sequence-to-expression modelling with chromatin accessibility.Bioinformatics (Oxford, England) · 2026Article
- Massively parallel reporter assays forbioRxiv : the preprint server for biology · 2026Article
- Multi-scale dissection, compaction and derivatization of mammalian developmental enhancers.bioRxiv : the preprint server for biology · 2026Article
- STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy.iScience · 2026Article
- An end-to-end generalizable deep learning framework to comprehensively analyze transcriptional regulation.Nature communications · 2026Article
- Boolean logic links chromatin accessibility states to gene expression variability across cell types.Nucleic acids research · 2026Article
- Modeling nascent transcription from chromatin landscape and structure with CLASTER.Genome biology · 2026Article
- Dual promoter-enhancer activities reflect a unified regulatory logic.Nature communications · 2026Article
- Enhancer-dependent gene regulation in space, time, and malignancies.International journal of cancer · 2026Review
- Deregulated enhancer-promoter communication in cancer through altered nuclear architecture.International journal of cancer · 2026Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Drew T Bergman *Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8314-7088
Thouis R Jones *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Vincent LiuDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6790-6603
Judhajeet RayBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1524-2603
Evelyn JagodaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Layla SirajBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Helen Y KangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Joseph NasserBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael KaneBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Antonio RiosDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6717-2267
Tung H NguyenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sharon R GrossmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Charles P FulcoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2662-4631
Jesse M EngreitzBroad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.ORCID http://orcid.org/0000-0002-5754-1719
Broad Institute · USStanford University · USLucile Packard Children's Hospital · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MINSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MMOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6MMapping enhancer-gene regulation in single cells to connect genetic variants to target genes and cell typesR35HG011324 · NHGRI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2020 to 2024
$2.3MCOMPUTATIONAL METHODS FOR PROTEOMIC ANALYSISK22HG000044 · NHGRI · UNIVERSITY OF UTAH · PI GIDDINGS, MORGAN CORINNE · 2000 to 2005
$1.3MSystematic mapping and prediction of gene-enhancer connectionsR00HG009917 · NHGRI · STANFORD UNIVERSITY · PI ENGREITZ, JESSE M · 2020 to 2022
$796kSystematic mapping and prediction of gene-enhancer connectionsK99HG009917 · NHGRI · BROAD INSTITUTE, INC. · PI ENGREITZ, JESSE M · 2018 to 2019
$65kNHGRI NIH HHS K22 HG000044NHGRI NIH HHS K99 HG009917NHGRI NIH HHS R00 HG009917NHGRI NIH HHS R35 HG011324NHGRI NIH HHS T32 HG000044NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM008313
Abstract
Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters
Indexed as
Enhancer Elements, GeneticPromoter Regions, GeneticHumansRNATranscription FactorsRNATranscription Factors
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.