Evidence map›Paper›PMID 35594415›Full record

ArticleACS chemical biology2022

R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures.

Anita Donlic, Emily G Swanson, Liang-Yuan Chiu, Sarah L Wicks, Aline Umuhire Juru, Zhengguo Cai, Kamillah Kassam, Chris Laudeman, Bilva G Sanaba, Andrew Sugarman and 3 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Machine Learning for RNA-Targeting Drug Design.Journal of chemical information and modeling · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. ACS chemical biology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Molecular insights into de novo small-molecule recognition by an intron RNA structure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Ligand-binding pockets in RNA and where to find them.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anita DonlicDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08540, United States.
Emily G SwansonDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Liang-Yuan ChiuDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 441106, United States.
Sarah L WicksDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Aline Umuhire JuruDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Zhengguo CaiDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Kamillah KassamDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Chris LaudemanDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Bilva G SanabaDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Andrew SugarmanDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 441106, United States.
Eunseong HanDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.
Blanton S TolbertDepartment of Chemistry, Case Western Reserve University, Cleveland, Ohio 441106, United States.ORCID 0000-0003-2456-0443
Amanda E HargroveDepartment of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27705, United States.ORCID 0000-0003-1536-6753

Funding

Center for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1M
The Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BIENIASZ, PAUL D. · 2019 to 2021
$15.1M
Harnessing Small Molecules to Probe the Structure and Function of Regulatory RNAsR35GM124785 · NIGMS · DUKE UNIVERSITY · PI HARGROVE, AMANDA E · 2017 to 2023
$2.8M
Structural Biophysics of HIV Splicing and Transcriptional ControlR01AI150830 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TOLBERT, BLANTON SMITH · 2020 to 2023
$2.2M
Quantum Helium Recovery SystemR01GM126833 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI BREWER, GARY A., TOLBERT, BLANTON SMITH · 2018 to 2021
$1.9M
STRUCTURAL BIOPHYSICS OF HIV ALTERNATIVE SPLICINGR01GM101979 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI TOLBERT, BLANTON SMITH · 2012 to 2016
$1.6M
NIAID NIH HHS L60 AI154614NIAID NIH HHS R01 AI150830NIAID NIH HHS U54 AI150470NIAID NIH HHS U54 AI170660NIGMS NIH HHS R01 GM101979NIGMS NIH HHS R01 GM126833NIGMS NIH HHS R35 GM124785
6 · The paper itself

Abstract

Discoveries of RNA roles in cellular physiology and pathology are increasing the need for new tools that modulate the structure and function of these biomolecules, and small molecules are proving useful. In 2017, we curated the

Indexed as

RNASmall Molecule LibrariesDatabases, Nucleic AcidLigandsRNA ProbesLigandsRNARNA ProbesSmall Molecule Libraries

Identifiers

PMID35594415
PMCPMC9343015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.