ArticleProceedings of the National Academy of Sciences of the United States of America2022
A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Differential contributions of striatal dopaminergic pathways to visuomotor conditional learning.Psychopharmacology · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Article
- Dopamine in the ventral and tail of striatum supports global and local evaluation in reward-threat conflict.bioRxiv : the preprint server for biology · 2026Article
- Article
- In vivo multimodal neurochemical interfaces for real-time decoding of brain circuit.Nature reviews. Neuroscience · 2026Review
- Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Nucleus accumbens DRD2 receptor agonism attenuates escape behavior.Frontiers in neuroscience · 2026Article
- Abstinence and extinction drive opposing changes in striatal activity and dopamine signaling during alcohol relapse.Neuropharmacology · 2025Article
- Aversion-induced dopamine reductions predict drug-taking and escape behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Striatal dopamine signals errors in prediction across different informational domains.Science advances · 2025Article
- Article
- Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations.Nature communications · 2025Article
- Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum regulate affect and motor control.iScience · 2025Article
- Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons.Nature communications · 2025Article
- Representation of Anticipated Rewards and Punishments in the Human Brain.Annual review of psychology · 2025Review
- Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation.Cell reports · 2024Article
- Comparison of dopamine release and uptake parameters across sex, species and striatal subregions.The European journal of neuroscience · 2024Article
- Aversion-induced drug taking and escape behavior involve similar nucleus accumbens core dopamine signaling signatures.bioRxiv : the preprint server for biology · 2024Article
- Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning.Current biology : CB · 2024Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Dopamine signals in the striatum are critical for motivated behavior. However, their regional specificity and precise information content are actively debated. Dopaminergic projections to the striatum are topographically organized. Thus, we quantified dopamine release in response to motivational stimuli and associated predictive cues in six principal striatal regions of unrestrained, behaving rats. Absolute signal size and its modulation by stimulus value and by subjective state of the animal were interregionally heterogeneous on a medial to lateral gradient. In contrast, dopamine-concentration direction of change was homogeneous across all regions: appetitive stimuli increased and aversive stimuli decreased dopamine concentration. Although cues predictive of such motivational stimuli acquired the same influence over dopamine homogeneously across all regions, dopamine-mediated prediction-error signals were restricted to the ventromedial, limbic striatum. Together, our findings demonstrate a nuanced striatal landscape of unidirectional but not uniform dopamine signals, topographically encoding distinct aspects of motivational stimuli and their prediction.
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