Evidence map›Paper›PMID 35594397›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.

Yu-Chin Chen, Viet Ton That, Chidi Ugonna, Yilin Liu, Lynn Nadel, Ying-Hui Chou

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu-Chin ChenDepartment of Psychology, University of Arizona, Tucson, AZ 85721.ORCID 0000-0002-5053-7688
Viet Ton ThatDepartment of Psychology, University of Arizona, Tucson, AZ 85721.
Chidi UgonnaDepartment of Psychology, University of Arizona, Tucson, AZ 85721.
Yilin LiuDepartment of Psychology, University of Arizona, Tucson, AZ 85721.
Lynn NadelDepartment of Psychology, University of Arizona, Tucson, AZ 85721.ORCID 0000-0001-5854-2206
Ying-Hui ChouDepartment of Psychology, University of Arizona, Tucson, AZ 85721.ORCID 0000-0003-0707-286X
University of Arizona · US

Funding

Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic StimulationR01AG062543 · NIA · UNIVERSITY OF ARIZONA · PI CHOU, YING-HUI · 2020 to 2024
$3.5M
Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive ImpairmentR21AG077153 · NIA · UNIVERSITY OF ARIZONA · PI CHOU, YING-HUI · 2022 to 2023
$409k
NIA NIH HHS R01 AG062543NIA NIH HHS R21 AG077153
6 · The paper itself

Abstract

Mild cognitive impairment (MCI) during aging is often a harbinger of Alzheimer’s disease, and, therefore, early intervention to preserve cognitive abilities before the MCI symptoms become medically refractory is particularly critical. Functional MRI–guided transcranial magnetic stimulation is a promising approach for modulating hippocampal functional connectivity and enhancing memory in healthy adults. Here, we extend these previous findings to individuals with MCI and leverage theta burst stimulation (TBS) and white matter tractography derived from diffusion-weighted MRI to target the hippocampus. Our preliminary findings suggested that TBS could be used to improve associative memory performance and increase resting-state functional connectivity of the hippocampus and other brain regions, including the occipital fusiform, frontal orbital cortex, putamen, posterior parahippocampal gyrus, and temporal pole, along the inferior longitudinal fasciculus in MCI. Although the sample size is small, these results shed light on how TBS propagates from the superficial cortex around the parietal lobe to the hippocampus.

Indexed as

Cognitive DysfunctionMemoryWhite MatterDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingTranscranial Magnetic Stimulationmagnetic resonance imagingmemorymild cognitive impairmenttheta burst stimulationtranscranial magnetic stimulation

Identifiers

PMID35594397
PMCPMC9173759
OpenAlexW4280546963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.