ArticleScience advances2022
Gelation of highly entangled hydrophobic macromolecular fluid for ultrastrong underwater in situ fast tissue adhesion.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- Macroscopic assembly of supramolecular coacervates for underwater adhesion.Nature communications · 2026Article
- Injectable Hydrogel with Rapid Coagulation, Low Swelling, and High Burst Pressure Tolerance Properties for Long-Term Management of Bleeding Wound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Machine learning-guided design of mechanoadaptive bioglues for multitissue trauma and first-aid applications.Nature biomedical engineering · 2026Article
- Bioinspired ionic thermoreceptors with anisotropic architecture for thermotactile perception in robots.Science advances · 2026Article
- Recent advances onFundamental research · 2026Review
- Engineered blood clots stop bleeding in seconds.Nature · 2026Article
- Biodegradable Adhesive Systems for Bio-Integrated Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Locking small solvents by hypercrosslinked polymers towards sterically hindered organogels.Nature communications · 2025Article
- Solution-sheared supramolecular oligomers with enhanced thermal resistance in interfacial adhesion and bulk cohesion.Nature communications · 2025Article
- Role of chemistry in nature-inspired skin adhesives.Chemical science · 2025Review
- Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding.Bioactive materials · 2025Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- Platelet Vesicles Synergetic with Biosynthetic Cellulose Aerogels for Ultra-Fast Hemostasis and Wound Healing.Advanced healthcare materials · 2024Article
- Wetting-enhanced adhesion of photo-polymerized supramolecular adhesives for both smooth and rough surfaces.Chemical science · 2024Article
- Low-impedance tissue-device interface using homogeneously conductive hydrogels chemically bonded to stretchable bioelectronics.Science advances · 2024Article
- Hydrophobic Polystyrene-Modified Gelatin Enhances Fast Hemostasis and Tissue Regeneration in Traumatic Brain Injury.Advanced healthcare materials · 2023Article
- Tunable backbone-degradable robust tissue adhesives via in situ radical ring-opening polymerization.Nature communications · 2023Article
- Development of Organs-on-Chips and Their Impact on Precision Medicine and Advanced System Simulation.Pharmaceutics · 2023Review
- Molecular architecture regulation for the design of instant and robust underwater adhesives.Science advances · 2023Article
- Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although strong underwater bioadhesion is important for many biomedical applications, designing adhesives to perform in the presence of body fluids proves to be a challenge. To address this, we propose an underwater and in situ applicable hydrophobic adhesive (UIHA) composed of polydimethylsiloxane, entangled macromolecular silicone fluid, and a reactive silane. The hydrophobic fluid displaced the boundary water, formed an in situ gel, bonded to tissues, and achieved exceptional underwater adhesion strength. Its underwater lap shear adhesion on porcine skin was significantly higher than that of cyanoacrylate and fibrin glues, demonstrating excellent water resistance. The burst pressure of UIHA on porcine skin was 10 times higher than that of fibrin glue. The cytocompatible UIHA successfully sealed ruptured arteries, skin, and lungs in rats, pigs, rabbits, and dogs. Together, the gelation of highly entangled hydrophobic macromolecular fluid provided a means to prepare underwater bioadhesives with strong bonding to tissues and excellent water resistance.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.