Evidence map›Paper›PMID 35594269›Full record

ArticlePloS one2022

Automatic reagent handling and assay processing of human biospecimens inside a transportation container for a medical disaster response against radiation.

Adam R Akkad, Jian Gu, Brett Duane, Alan Norquist, David J Brenner, Adarsh Ramakumar, Frederic Zenhausern

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adam R AkkadCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ, United States of America.
Jian GuCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ, United States of America.ORCID 0000-0001-6081-9155
Brett DuaneCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ, United States of America.
Alan NorquistCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ, United States of America.
David J BrennerCenter for Radiological Research, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, United States of America.
Adarsh RamakumarArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America.
Frederic ZenhausernCenter for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine, Phoenix, AZ, United States of America.
University of Arizona · USColumbia University · USUniformed Services University of the Health Sciences · US

Funding

Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AMUNDSON, SALLY A. · 2005 to 2024
$105.4M
NIAID NIH HHS U19 AI067773
6 · The paper itself

Abstract

Biological materials can be shipped off-site for diagnostic, therapeutic and research purposes. They usually are kept in certain environments for their final application during transportation. However, active reagent handling during transportation from a collection site to a laboratory or biorepository has not been reported yet. In this paper, we show the application of a micro-controlled centrifugal microfluidic system inside a shipping container that can add reagent to an actively cultured human blood sample during transportation to ensure a rapid biodosimetry of cytokinesis-block micronucleus (CBMN) assay. The newly demonstrated concept could have a significant impact on rapid biodosimetry triage for medical countermeasure in a radiological disaster. It also opens a new capability in accelerated sample processing during transportation for biomedical and healthcare applications.

Indexed as

DisastersRadiometryCytokinesisHumansIndicators and ReagentsMicronucleus TestsIndicators and Reagents

Identifiers

PMID35594269
PMCPMC9122182
OpenAlexW4280606293

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.