ArticlePloS one2022
Differential gene expression profile of multinodular goiter.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Transcriptomic analysis reveals a critical role for activating GScientific reports · 2024Article
- Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics.Archives of endocrinology and metabolism · 2024Article
- Correlation between thyroid function indices and urine iodine levels in patients with nodular goiter.American journal of translational research · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe goiter, a neglected heterogeneous molecular disease, remains a major indication for thyroidectomies in its endemic regions.
objectivesThis study analyzed differential gene expression in surgical specimens diagnosed with multi nodular and compared the data to that of thyroid tissue without multinodular goiter from patients undergoing thyroidectomy in Manaus-AM, Brazil using RNA-seq technology. METHODOLOGY: The transcriptome information of the surgical specimen fragments with and without multinodular goiter was accessed by Illumina HiSeq 2000 New Generation Sequencing (NGS) using the RNA-seq NEBNext® Ultra™ RNA Library Prep Kit for Illumina®-#E7530L protocol and differential gene expression analysis.
resultsDifferences were found between the gene expression profiles of the diseased tissues and those of the healthy control tissues; at least 70 genes were differentially expressed. The HOTS gene was expressed only in multinodular goiter tissues (p < 0.05).
conclusionThese results demonstrate that the gene expression profile of multinodular goiter is pro-tumoral and that HOTS can play a central role in multinodular goiter development.
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