ArticleeLife2022
Lead-OR: A multimodal platform for deep brain stimulation surgery.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- ACPC-MAP: a protocol for manually aligning structural T1-weighted magnetic resonance images to the anterior commissure - posterior commissure plane according to clinical standards.Brain structure & function · 2026Article
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Advancing AADC deficiency therapy through MR-guided multisite delivery of AAV2-hAADC to dopaminergic and serotonergic pathways in the brainstem.Molecular therapy. Advances · 2026Article
- Hyperdirect projections from the supplementary motor area mediate subthalamic stimulation effects on movement initiation and inhibition in Parkinson's disease.Brain communications · 2026Article
- LFP-LOC: an LFP power-based method for validating the anatomical placement of high-density neural probes in rodents.Frontiers in neuroscience · 2026Article
- Precise Electrode Co-Alignment in Deep Brain Stimulation Fusing Neuroimaging and Electrophysiology.The European journal of neuroscience · 2025Article
- Is the Subthalamic Nucleus Sleeping Under Nitrous Oxide-Ketamine General Anesthesia?The European journal of neuroscience · 2025Article
- A roadmap towards standardized neuroimaging approaches for human thalamic nuclei.Nature reviews. Neuroscience · 2024Review
- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
- Investigation of the mechanism of action of deep brain stimulation for the treatment of Parkinson's disease.Cognitive neurodynamics · 2024Article
- A ubiquitous spectrolaminar motif of local field potential power across the primate cortex.Nature neuroscience · 2024Article
- Article
- Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques.Science advances · 2023Article
- Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks.NeuroImage · 2023Article
- Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease.Nature communications · 2022Article
- Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Background: Deep brain stimulation (DBS) electrode implant trajectories are stereotactically defined using preoperative neuroimaging. To validate the correct trajectory, microelectrode recordings (MERs) or local field potential recordings can be used to extend neuroanatomical information (defined by MRI) with neurophysiological activity patterns recorded from micro- and macroelectrodes probing the surgical target site. Currently, these two sources of information (imaging vs. electrophysiology) are analyzed separately, while means to fuse both data streams have not been introduced. Methods: Here, we present a tool that integrates resources from stereotactic planning, neuroimaging, MER, and high-resolution atlas data to create a real-time visualization of the implant trajectory. We validate the tool based on a retrospective cohort of DBS patients (N = 52) offline and present single-use cases of the real-time platform. Results: We establish an open-source software tool for multimodal data visualization and analysis during DBS surgery. We show a general correspondence between features derived from neuroimaging and electrophysiological recordings and present examples that demonstrate the functionality of the tool. Conclusions: This novel software platform for multimodal data visualization and analysis bears translational potential to improve accuracy of DBS surgery. The toolbox is made openly available and is extendable to integrate with additional software packages. Funding: Deutsche Forschungsgesellschaft (410169619, 424778381), Deutsches Zentrum für Luft- und Raumfahrt (DynaSti), National Institutes of Health (2R01 MH113929), and Foundation for OCD Research (FFOR).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.