Evidence map›Paper›PMID 35594040›Full record

ArticleTranslational vision science & technology2022

Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device.

Anna M Waldie, Angharad E Hobby, Isabelle Chow, Elisa E Cornish, Mathura Indusegaran, Aleksandra Pekacka, Phuc Nguyen, Clare Fraser, Alison M Binns, Miles R Stanford and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. The reproducibility of handheld ERGs recorded with skin electrode and natural pupils.Documenta ophthalmologica. Advances in ophthalmology · 2025
    Article
  4. Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Anna M WaldieSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Angharad E HobbySection of Ophthalmology, King's College London, London, UK.
Isabelle ChowSection of Ophthalmology, King's College London, London, UK.
Elisa E CornishSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Mathura IndusegaranSection of Ophthalmology, King's College London, London, UK.
Aleksandra PekackaSection of Ophthalmology, King's College London, London, UK.
Phuc NguyenSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Clare FraserSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Alison M BinnsDivision of Optometry and Visual Sciences, City, University of London, London, UK.
Miles R StanfordSection of Ophthalmology, King's College London, London, UK.
Christopher J HammondSection of Ophthalmology, King's College London, London, UK.
Peter J McCluskeySave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
John R GriggSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Omar A MahrooSection of Ophthalmology, King's College London, London, UK.
University of Sydney · AUKing's College London · GBSt Thomas' Hospital · GBCity, University of London · GBGuy's and St Thomas' NHS Foundation Trust · GBMoorfields Eye Hospital · GB

Funding

Department of HealthWellcome Trust 206619/Z/17/Z
6 · The paper itself

Abstract

Purpose: The flicker electroretinogram (ERG) is a sensitive indicator of retinal dysfunction in birdshot chorioretinopathy (BCR). We explored recordings from a handheld device in BCR, comparing these with conventional recordings in the same patients and with handheld ERGs from healthy individuals. Methods: Non-mydriatic flicker ERGs, using the handheld RETeval system (LKC Technologies), were recorded with skin electrodes at two centers. At one center (group 1), the stimuli (85 Td·s, 850 Td background) delivered retinal illuminance equivalent to international standards; at the other center (group 2), a different protocol was used (32 Td·s, no background). Patients also underwent international standard flicker ERG recordings with conventional electrodes following mydriasis. Portable ERGs from patients were also compared with those from healthy individuals. Results: Thirty-two patients with BCR (mean age ± SD, 56.4 ± 11.3 years) underwent recordings. Portable and standard ERG parameters correlated strongly (r > 0.75, P < 0.01) in both groups. Limits of agreement for peak times were tighter in group 1 (n = 21; -4.3 to +2.0 ms [right eyes], -3.9 to 1.5 ms [left eyes]) than in group 2 (n = 11; -3.4 to +6.9 ms [right eyes], -4.8 to +9.0 ms [left eyes]). Compared with healthy controls (n = 66 and n = 90 for groups 1 and 2, respectively), patients with BCR showed smaller mean amplitudes and longer peak times. Conclusions: Portable ERGs correlated strongly with conventional recordings, suggesting potential in rapid assessment of cone system function in office settings. Translational Relevance: Flicker ERGs, known to be useful in BCR, can be obtained rapidly with a portable device with skin electrodes and natural pupils.

Indexed as

ElectroretinographyRetinaBirdshot ChorioretinopathyHumansPhotic StimulationPupil

Identifiers

PMID35594040
PMCPMC9145202
OpenAlexW4281263975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.