Evidence map›Paper›PMID 35594022›Full record

ArticleAdvances in experimental medicine and biology2022

Vaccines and Immunoinformatics for Vaccine Design.

Shikha Joon, Rajeev K Singla, Bairong Shen

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Design of a novel multi-epitope vaccine candidate againstBiochemistry and biophysics reports · 2024
    Article
  9. Article
  10. A New Strategy for Mapping Epitopes of LACK and PEPCK Proteins ofInternational journal of molecular sciences · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shikha Joon *Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Rajeev K Singla *Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Bairong ShenInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. bairong.shen@scu.edu.cn.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host immune system recognizes and responds to the selective antigens or epitopes (immunome) of the intruding pathogen over an entire organism. The immune response so generated is ample to confer the desired immunity and protection to the host. This led to the conception of immunome-derived vaccines that exploit selective genome-derived antigens or epitopes from the pathogen's immunome and not its entire genome or proteome. These are designed to elicit the required immune response and confer protection against future invasions by the same pathogen. Immunoinformatics through its epitope mapping tools allows direct selection of antigens from a pathogen's genome or proteome, which is critical for the generation of an effective vaccine. This paved way for novel vaccine design strategies based on the mapped epitopes for translational applications that includes prophylactic, therapeutic, and personalized vaccines. In this chapter, various Immunoinformatics tools for epitope mapping are presented along with their applications. The methodology for immunoinformatics-assisted vaccine design is also outlined.

Indexed as

Epitopes, T-LymphocyteVaccinesComputational BiologyEpitope MappingMolecular Docking SimulationProteomeVaccines, SubunitEpitopes, T-LymphocyteProteomeVaccinesVaccines, SubunitAntigensEpitope mappingEpitopesImmunoinformaticsImmunomeImmunome-derived vaccines

Identifiers

PMID35594022
OpenAlexW4285165723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.