ArticleJournal of fluorescence2022
An AIE-Active probe for detection and bioimaging of pH values based on lactone hydrolysis reaction.
Article in Journal of fluorescence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- 3-Aroylbenzocoumarin-Based Luminogens: Bright Solid-State Emission, AIE Properties and Cell Imaging Application.Journal of fluorescence · 2025Article
- Decomposition of Unpolarized Fluorescence Spectrum of Uniaxially Oriented 1,3,5-Triphenylbenzene Microcrystals Into Polarized Fluorescence Spectra.Journal of fluorescence · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cellular pH homeostasis is essential for many physiological and pathological processes. pH monitoring is helpful for the diagnosis, treatment and prevention of disorders and diseases. Herein, we developed a ratiometric fluorescent pH probe (TCC) based on a coumarin derivative containing a highly active lactone ring. TCC exhibited a typical AIE effect and emitted blue fluorescence under weak acidic condition. When under weak basic condition, the active lactone moiety underwent a hydrolysis reaction to afford a water-soluble product, which gave red-shifted emission. The emission color change from blue through cyan and then to yellow within pH 6.5-9.0 which is approximate to the biological pH range. And the fluorescence color change along with pH value is reversible. Furthermore, TCC was successfully utilized in the detection of the intracellular pH change of live HeLa cells, which indicated that TCC had practical potential in biomedical research.
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Registered trials
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