ArticleeLife2022
Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Convergent and Divergent Connectivity Patterns of the Arcuate Fasciculus in Macaques and Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization.Nature methods · 2025Article
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small-animal imaging.Magnetic resonance in medicine · 2025Review
- Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level.bioRxiv : the preprint server for biology · 2025Article
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- Self-supervised segmentation and characterization of fiber bundles in anatomic tracing data.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Clustered architecture of ipsilateral and interhemispheric connections in macaque ventrolateral prefrontal cortex.Frontiers in neural circuits · 2025Article
- State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- A complementary approach for neocortical cytoarchitecture inspection with cellular resolution imaging at whole brain scale.Frontiers in neuroanatomy · 2024Article
- Review
- Imaging crossing fibers in mouse, pig, monkey, and human brain using small-angle X-ray scattering.Acta biomaterialia · 2023Article
- Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys.Nature communications · 2023Article
- Mapping Human Brain Pathways: Challenges and Opportunities in the Integration of Scales.Brain, behavior and evolution · 2023Review
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resolving trajectories of axonal pathways in the primate prefrontal cortex remains crucial to gain insights into higher-order processes of cognition and emotion, which requires a comprehensive map of axonal projections linking demarcated subdivisions of prefrontal cortex and the rest of brain. Here, we report a mesoscale excitatory projectome issued from the ventrolateral prefrontal cortex (vlPFC) to the entire macaque brain by using viral-based genetic axonal tracing in tandem with high-throughput serial two-photon tomography, which demonstrated prominent monosynaptic projections to other prefrontal areas, temporal, limbic, and subcortical areas, relatively weak projections to parietal and insular regions but no projections directly to the occipital lobe. In a common 3D space, we quantitatively validated an atlas of diffusion tractography-derived vlPFC connections with correlative green fluorescent protein-labeled axonal tracing, and observed generally good agreement except a major difference in the posterior projections of inferior fronto-occipital fasciculus. These findings raise an intriguing question as to how neural information passes along long-range association fiber bundles in macaque brains, and call for the caution of using diffusion tractography to map the wiring diagram of brain circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.