Evidence map›Paper›PMID 35593749›Full record

ArticleThe American surgeon2023

Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.

Ethan D Carmichael, Camille G Apple, Kolenkode B Kannan, Anna Gardener, Stephen Anton, Philip A Efron, Lyle L Moldawer, Frederick A Moore, Scott C Brakenridge, Alicia M Mohr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American surgeon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ethan D CarmichaelDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Camille G AppleDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Kolenkode B KannanDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Anna GardenerDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Stephen AntonDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Philip A EfronDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Lyle L MoldawerDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Frederick A MooreDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Scott C BrakenridgeDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.
Alicia M MohrDepartment of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.ORCID 0000-0003-1732-1313
University of Florida Health · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893
6 · The paper itself

Abstract

introductionSurvivors of sepsis will progress towards rapid recovery (RAP) or enter a state of persistent organ dysfunction and chronic critical illness (CCI). Independently, anemia is known to be a significant factor in functional recovery of hospitalized patients. This study aims to analyze long-term hemoglobin levels and functional outcomes following RAP and CCI.

methodsA prospective, cohort study was performed in septic patients who were stratified into RAP (N = 54) with ICU length of stay < 14 days or CCI (N = 63) with ICU length of stay > 14 days. CBC and plasma inflammatory markers were measured on the day of enrollment, weekly until day 42, then at 3 and 6 months. Functional outcomes using Zubrod scale, gait speed test, and total short physical performance battery (SPPB) were assessed at 3, 6, and 12 months.

resultsMean age was 59 years (range: 20-83) and 62% were male. Hemoglobin was significantly decreased at 3 and 6 months in CCI compared to RAP (8.9* and 9.2* vs 10.4 and 11.1 g/dL), despite receiving significantly more red blood cell transfusions. CCI patients had persistent elevation of CRP, IL-6 and TNF-α. CCI patients had worse functional outcome with a significantly higher Zubrod score, and lower SPPB, and gait speed score at 3, 6, and 12 months.

conclusionDespite receiving more pRBC transfusions, CCI patients had a persistent anemia that was associated with chronic systemic inflammation and poor functional outcomes six months following sepsis. Alleviating prolonged inflammation could improve persistent anemia and functional outcomes in CCI patients.

Indexed as

AnemiaSepsisCohort StudiesCritical IllnessFemaleHumansInflammationIntensive Care UnitsMaleMiddle AgedProspective StudiesanemiaC-reactive proteinfunctional outcomesinterleukin-6sepsis

Identifiers

PMID35593749
PMCPMC9675873
OpenAlexW4280634635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.