Evidence map›Paper›PMID 35593518›Full record

ArticleBirth defects research2022

Lesion-specific mortality due to congenital heart disease in U.S. adults from 1999 to 2017.

Melodie M Lynn, Jason L Salemi, Callie J Meath, Stephen J Dolgner, Shaine A Morris, S Kristen Sexson Tejtel, Keila N Lopez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melodie M LynnDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0003-2684-0027
Jason L SalemiCollege of Public Health, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-0077-6023
Callie J MeathBaylor College of Medicine, Houston, Texas, USA.
Stephen J DolgnerDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0003-4482-8187
Shaine A MorrisDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0002-8056-0934
S Kristen Sexson TejtelDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0001-7584-8450
Keila N LopezDivision of Pediatric Cardiology, Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA.ORCID 0000-0002-2710-6257
Baylor College of Medicine · USUniversity of South Florida · US

Funding

Building Mobile Technologies to Reduce Health Disparities in Congenital Heart DiseaseK23HL127164 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LOPEZ, KEILA NATILDE · 2016 to 2021
$856k
NHLBI NIH HHS K23 HL127164
6 · The paper itself

Abstract

backgroundAdults with congenital heart disease (ACHD) comprise an increasing proportion of individuals living with CHD in the United States (US) although little is known regarding lesion or age-specific mortality in the modern era. Our study aimed to describe current era ACHD mortality rates by age and CHD lesion and provide temporal mortality rate trends for the last two decades.

methodsWe conducted a 19-year analysis (1999-2017) of publicly available, de-identified Multiple Cause of Death data compiled and produced by the National Center for Health Statistics. Age and lesion-specific mortality rates were calculated using joinpoint regression.

resultsACHD mortality rates decreased by an average of 2%-4% per year for all adults. CHD lesions resulting in the highest ACHD-related mortality varied by age. Unlike the other lesions, mortality attributed to single ventricle physiology failed to improve in early adulthood (average of 1.6% increase per year). In decedents age 65 years or older, simpler forms of CHD like shunt lesions became more prominent contributors, accounting for 46% of deaths.

conclusionRates of mortality due to ACHD have declined significantly for adults with CHD, however, continued mortality due to single ventricle physiology remains an area requiring improved strategies to increase survival.

Indexed as

Heart Defects, CongenitalAdultAgedHumansUnited Statescongenital heart defectsepidemiologyFontan procedurehealth care outcome assessment

Identifiers

PMID35593518
PMCPMC9629143
OpenAlexW4281257128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.