Evidence map›Paper›PMID 35593403›Full record

ArticleIntegrative cancer therapies

The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers.

Dedy Hermansyah, Felix Zulhendri, Conrad O Perera, Naufal N Firsty, Kavita Chandrasekaran, Rizky Abdulah, Herry Herman, Ronny Lesmana

Open access · goldAbstract read
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. An Updated Review Summarizing the Anticancer Potential of Naringenin.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dedy HermansyahUniversitas Sumatera Utara, Medan, Indonesia.
Felix ZulhendriUniversitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-7881-1845
Conrad O PereraUniversity of Auckland, Auckland, New Zealand.
Naufal N FirstyUniversitas Sumatera Utara, Medan, Indonesia.ORCID 0000-0003-1668-6660
Kavita ChandrasekaranPeerzadiguda, Hyderabad, Telangana, India.
Rizky AbdulahUniversitas Padjadjaran, Bandung, Indonesia.
Herry HermanUniversitas Padjadjaran, Bandung, Indonesia.
Ronny LesmanaUniversitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0002-7425-915X
Padjadjaran University · IDUniversitas Sumatera Utara · IDUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propolis is a resinous beehive product that has a wide range of biological activities, namely antimicrobial, antioxidant, and anti-inflammatory properties. Propolis is collected by the bees from plant resin and exudates to protect hives and maintain hive homeostasis. The aim of the present systematic scoping review is to explore the potential and suitability of propolis as an adjunctive treatment in breast cancers, based on the latest available experimental evidence (2012-2021). After applying the exclusion criteria, a total of 83 research publications were identified and retrieved from Scopus, Web of Science, and Pubmed. Several relevant key themes identified from the included studies were cytotoxicity, synergistic/combination treatment, improvement in bioavailability, human clinical trials, and others. A majority of the studies identified were still in the in vitro and in vivo stages. Nonetheless, we managed to identify 4 human clinical trials that demonstrated the successful use of propolis in alleviating side effects of chemotherapy and radiotherapy while increasing the quality of life of breast cancer patients, with minimal adverse effects. In conclusion, propolis, as an adjunctive treatment, may have therapeutic benefits in alleviating symptoms related to breast cancers. However, further clinical trials, preferably with higher number of participants/subjects/patients, are urgently needed.

Indexed as

Anti-Infective AgentsBreast NeoplasmsPropolisAntioxidantsFemaleHumansQuality of LifeAnti-Infective AgentsAntioxidantsPropolisadjunct therapycomplementary medicinenutraceuticalpropolissupportive caresystematic review

Identifiers

PMID35593403
PMCPMC9127854
OpenAlexW4281258238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.