Evidence map›Paper›PMID 35593120›Full record

ArticleFEBS letters2022

The transcription factor C/EBPβ promotes vascular endothelial growth factor A expression and neural stem cell expansion.

Yinghui Li, Jonathan Schor, Jonathan Bartko, George Albert, Marc W Halterman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yinghui LiDepartment of Neurology, Renaissance School of Medicine, Stony Brook University, NY, USA.
Jonathan SchorDepartment of Neurology, School of Medicine and Dentistry, The University of Rochester, NY, USA.
Jonathan BartkoDepartment of Neurology, School of Medicine and Dentistry, The University of Rochester, NY, USA.
George AlbertDepartment of Neurology, School of Medicine and Dentistry, The University of Rochester, NY, USA.
Marc W HaltermanDepartment of Neurology, Renaissance School of Medicine, Stony Brook University, NY, USA.ORCID 0000-0002-1022-8565
University of Rochester · USStony Brook School · US

Funding

Defining Neurotherapeutic Targets in Hypoxia-Induced CHOP-10 Signaling NetworksR00NS060764 · NINDS · UNIVERSITY OF ROCHESTER · PI HALTERMAN, MARC W · 2010 to 2012
$725k
Defining Neurotherapeutic Targets in Hypoxia-Induced CHOP-10 Signaling NetworksK99NS060764 · NINDS · UNIVERSITY OF ROCHESTER · PI HALTERMAN, MARC W · 2008 to 2009
$268k
NINDS NIH HHS K99 NS060764NINDS NIH HHS R00 NS060764
6 · The paper itself

Abstract

The bZIP transcription factor CCAAT-enhancer-binding protein β (C/EBPβ) exhibits neurogenic, neuritogenic, and pro-survival effects in the central nervous system. Here, we show that C/EBPβ regulates neural stem cell (NSC) expansion and vascular endothelial growth factor A (VEGF-A) level by acting on a C/EBPβ-responsive element within the Vegf-a promoter. As predicted, C/EBPβ depletion reduced VEGF-A production, NSC number, and average neurosphere size in proliferating cultures. Conversely, deletion of the C/EBPβ repressor CHOP-10 induced C/EBPβ and VEGF-A expression, while stimulating NSC expansion. These data highlight the role of C/EBPβ in regulating VEGF-A production and the growth of NSCs and suggest CHOP-dependent antagonism of C/EBPβ may function as a transcriptional rheostat linking stress-associated cues with stem cell quiescence among other pathological responses affecting the neurogenic niche.

Indexed as

Neural Stem CellsVascular Endothelial Growth Factor ACCAAT-Enhancer-Binding Protein-betaGene Expression RegulationPromoter Regions, GeneticCCAAT-Enhancer-Binding Protein-betaVascular Endothelial Growth Factor AbZIPC/EBPβCHOP-10neural stem cellVEGF-A

Identifiers

PMID35593120
PMCPMC9665899
OpenAlexW4280638658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.