Evidence map›Paper›PMID 35593083›Full record

ArticleDepression and anxiety2022

Association of adversity with psychopathology in early childhood: Dimensional and cumulative approaches.

Cheryl R Stein, Margaret A Sheridan, William E Copeland, Laura S Machlin, Kimberly L H Carpenter, Helen L Egger

Abstract read
In one paragraph

Article in Depression and anxiety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Adverse childhood experiences and psychopathology in adolescents from northern Chile: the moderating role of the attachment style.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2023
    Article
  10. Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheryl R SteinDepartment of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York City, New York, USA.ORCID 0000-0002-5866-0250
Margaret A SheridanDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
William E CopelandDepartment of Psychiatry, University of Vermont, Burlington, Vermont, USA.
Laura S MachlinDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kimberly L H CarpenterDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Helen L EggerDepartment of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York City, New York, USA.

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Neural pathways linking early adversity and preschool psychopathology to adolescent mental healthR01MH120314 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARPENTER, KIMBERLY L H, COPELAND, WILLIAM · 2020 to 2024
$3.8M
Preschool Anxiety Disorders in Primary CareR01MH075766 · NIMH · DUKE UNIVERSITY · PI ANGOLD, ADRIAN C · 2006 to 2010
$3.8M
NICHD NIH HHS P2C HD050924NIMH NIH HHS R01 MH075766NIMH NIH HHS R01MH075766NIMH NIH HHS R01 MH120314NIMH NIH HHS R01MH120314
6 · The paper itself

Abstract

backgroundThe association between adversity and psychopathology in adolescents and adults is characterized by equifinality. These associations, however, have not been assessed during early childhood when psychopathology first emerges. Defining adversity using both dimensional and cumulative risk approaches, we examined whether specific types of adversity are differentially associated with psychopathology in preschool-aged children.

methodsMeasures of threat, deprivation, and total adversities (i.e., cumulative risk) were calculated based on parent-reported information for 755 2- to 5-year old children recruited from pediatric primary care clinics. Logistic regression was used to estimate cross-sectional associations between type of adversity and anxiety, depression, ADHD, and behavioral disorder diagnoses.

resultsThreat and cumulative risk exhibited independent associations with psychopathology. Threat was strongly related to behavioral disorders. Cumulative risk was consistently related to all psychopathologies.

conclusionsUsing mutually adjusted models, we identified differential associations between threat and psychopathology outcomes in preschool-aged children. This selectivity may reflect different pathways through which adversity increases the risk for psychopathology during this developmentally important period. As has been observed at other ages, a cumulative risk approach also effectively identified the cumulative impact of all forms of adversity on most forms of psychopathology during early childhood.

Indexed as

Child AbuseMental DisordersAdolescentAdultAnxiety DisordersChildChild, PreschoolCross-Sectional StudiesHumansPsychopathologyabuseanxiety/anxiety disordersepidemiologymaltreatmentneglect

Identifiers

PMID35593083
PMCPMC9246999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.