ArticleAnnals of pediatric endocrinology & metabolism2022
Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam.
Article in Annals of pediatric endocrinology & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 12 citations in OpenAlex.
- Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings.Saudi medical journal · 2026Article
- Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- Development and Validation of a Prediction Model Using Sella Magnetic Resonance Imaging-Based Radiomics and Clinical Parameters for the Diagnosis of Growth Hormone Deficiency and Idiopathic Short Stature: Cross-Sectional, Multicenter Study.Journal of medical Internet research · 2024Article
- Comparison of the effect of gonadotropin-releasing hormone agonist dosage in girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2023Article
- Central precocious puberty with hypothalamic hamartoma: the first case reports of 2 siblings with different phenotypes of Seckel syndrome 5.Annals of pediatric endocrinology & metabolism · 2023Article
- Central precocious puberty: is routine brain MRI screening necessary for girls?: Commentary on "Brain magnetic resonance imaging (MRI) findings in central precocious puberty patients: is routine MRI necessary for newly diagnosed patients?"Annals of pediatric endocrinology & metabolism · 2023Article
- MRI evaluation of cranial pathologies in rapidly progressive early puberty cases aged 8-9.Frontiers in endocrinology · 2023Article
- Commentary on "Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam".Annals of pediatric endocrinology & metabolism · 2022Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeCranial magnetic resonance imaging (MRI) is recommended to identify intracranial lesions in girls with central precocious puberty (CPP). Yet, the use of routine MRI scans in girls with CPP is still debatable, as pathological findings in girls 6 years of age or older with CPP are limited. Therefore, we aimed to identify the prevalence of brain lessons in CPP patients stratified by age group (0-2, 2-6, and 6-8 years).
methodsThis retrospective cross-sectional study recruited 257 girls diagnosed with CPP for 6 years (2010-2016). MRI was used to detect brain abnormalities. Levels of luteinizing hormone, follicle-stimulating hormone, and sex hormones in blood samples were measured.
resultsMost girls had no brain lesions (82.9%, n=213), and of the minor proportion of girls with CPP that exhibited brain lesions (17.1%, n=44), 32 girls had organic CPP. Pathological findings were detected in 33.3% (2 of 6) of girls aged 0-2 years, 15.6% (5 of 32) of girls aged 2-6 years, and 3.6% (8 of 219) of girls aged 6-8 years. Hypothalamic hamartoma and tumors in the pituitary stalk were the most common pathological findings. The likelihood of brain lesions decreased with age. Girls with organic CPP were more likely to be younger (6.1±2.4 vs. 7.3±1.3 years, p<0.01) than girls with idiopathic CPP.
conclusionOlder girls appeared to have a lower prevalence of organic CPP. Clinicians should cautiously use cranial MRI for girls aged 6-8 years with CPP.
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