ReviewJournal of multidisciplinary healthcare2022
Association Between Symptoms and Severity of Disease in Hospitalised Novel Coronavirus (COVID-19) Patients: A Systematic Review and Meta-Analysis.
Review in Journal of multidisciplinary healthcare, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Initial insights into the relationship between symptomatic COVID-19 disease and specific clinical and blood parameters in patients with alcohol use disorder.Frontiers in public health · 2026Article
- COVID-19-Related Pathologies in Coronary Angiography in Patients with Acute Coronary Syndromes.Journal of clinical medicine · 2025Article
- Characteristics of symptoms among outpatients following the discontinuation of the dynamic zero-COVID-19 policy in China: insights from an online nationwide cross-sectional survey in 2022.Journal of thoracic disease · 2025Article
- Self-Reported Post-COVID Symptoms at 18 Months After Infection Among Adults in Southern Brazil: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Article
- The Impact of Long COVID on the Quality of Life.Medicina (Kaunas, Lithuania) · 2024Observational
- Pulmonary function trajectories in COVID-19 survivors with and without pre-existing respiratory disease.Scientific reports · 2024Article
- Association of Abnormal Cardiac Biomarkers and Cardiovascular Complications, with Mortality in Patients with SARS-CoV-2 Infection in Latin America.Journal of cardiovascular development and disease · 2024Article
- Article
- Morphological and Prognostic Values of Skin Lesions in Patients with COVID-19.Dermatology research and practice · 2024Article
- Lessons Learned from the Lived Experiences of COVID-19 ICU Survivors Who are Struggling Through Critical Conditions and Surviving to Champion Life: A Qualitative Study.Journal of multidisciplinary healthcare · 2024Article
- Cost-effectiveness analysis of isolation strategies for asymptomatic and mild symptom COVID-19 patients.Cost effectiveness and resource allocation : C/E · 2023Article
- Article
- Trajectory of Post-COVID Self-Reported Fatigue and Dyspnoea in Individuals Who Had Been Hospitalized by COVID-19: The LONG-COVID-EXP Multicenter Study.Biomedicines · 2023Article
- The clinical practice of palliative sedation in patients dying from COVID-19: a retrospective chart review.BMC palliative care · 2023Article
- Knowledge, attitudes, and practices toward COVID-19 prevention in Yemen: a community-based cross-sectional study.Frontiers in public health · 2023Article
- Association between pregnancy and severe COVID-19 symptoms in Qatar: A cross-sectional study.PLOS global public health · 2023Article
- Machine learning-driven development of a disease risk score for COVID-19 hospitalization and mortality: a Swedish and Norwegian register-based study.Frontiers in public health · 2023Article
- No Association Between Ct Value and COVID-19 Severity and Mortality in Qatar.International journal of general medicine · 2023Article
- Assessing Associations Between COVID-19 Symptomology and Adverse Outcomes After Piloting Crowdsourced Data Collection: Cross-sectional Survey Study.JMIR formative research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Symptoms of the novel coronavirus disease (COVD-19) are well known, although asymptomatic cases were also reported due to this rapidly evolving viral disease. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and disease severity. We aimed to evaluate the association between symptoms and severity of disease in adult patients with confirmed COVID-19 by performing a meta-analysis. Methods: We conducted this study by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease between January 1, 2020, and October 31, 2021. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Note that we included peer-reviewed studies conducted in Wuhan and published in the English language that reported the clinical characteristics of COVID-19, particularly the symptoms of novel coronavirus patients with their prevalence and distribution of patients based on the severity of the disease. Results: Out of 255 articles identified, a total of twenty articles, including 5390 participants, met the inclusion criteria and were included. Among the participants, 2997 (55.60%) were males, and 974 (18.07%) reported severe conditions. Fever was the most commonly reported symptom in the reported COVID-19 confirmed cases (88.47%, 95% CI: 80.74-93.35%), which was followed by cough, fatigue, and less proportionally dyspnea and myalgia. Dyspnea was the only symptom, which was associated with severity of COVID-19 (OR 2.43, 95% CI: 1.52-3.89). Conclusion: Dyspnoea was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases need to be careful about the onset of such symptom and should seek medical attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.