ArticleFrontiers in endocrinology2022
The Association Between Serum Palmitic Acid and Thyroid Function.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association between fatty acid profile and normal thyroid hormone with different glucose status.BMC endocrine disorders · 2026Observational
- Weight-adjusted waist index and mortality in diabetic retinopathy: a NHANES 1999-2018 cohort study.Diabetology & metabolic syndrome · 2025Article
- Identifying the metabolic profile of Hashimoto's thyroiditis from the METHAP clinical study.Scientific reports · 2025Article
- Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The association between circulating saturated fatty acids and thyroid function: results from the NHANES 2011-2012.Frontiers in endocrinology · 2024Article
- Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals.Journal of endocrinological investigation · 2023Article
- Alterations in Faecal and Serum Metabolic Profiles in Patients with Neovascular Age-Related Macular Degeneration.Nutrients · 2023Article
- Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves' Disease.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- FT3/FT4 ratio is correlated with all-cause mortality, cardiovascular mortality, and cardiovascular disease risk: NHANES 2007-2012.Frontiers in endocrinology · 2022Article
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8 authors.
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Abstract
Aim: Emerging evidence indicates that palmitic acid (PA) can regulate the progression and development of many diseases. However, the studies examining the association between PA and thyroid function remain sparse. We aimed to investigate the association between serum PA (sPA) and thyroid function in the US population. Methods: In this retrospective study, a cross-sectional analysis was performed using the data pooled from the database of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012. The thyroid parameters investigated were mainly free triiodothyronine (FT3), free thyroxine (FT4), total T3 (TT3), TT4, thyroglobulin (Tg), thyroid-stimulating hormone (TSH), anti-thyroglobulin antibody (TgAb), and anti-thyroperoxidase antibody (TPOAb). The central sensitivity to thyroid function was evaluated by the thyroid feedback quantile-based index (TFQI), thyrotrophin thyroxine resistance index (TT4RI), and thyrotropin index (TSHI). The FT3 to FT4 ratio (FT3/FT4) was employed to evaluate peripheral sensitivity to thyroid hormones. Multiple imputation was applied to handle the missing data, and weighted multivariable linear regression, subgroup, and interaction analyses were then employed to estimate the association between sPA and thyroid parameters. Results: In the 737 adults, after adjusting covariates, we demonstrated a significant negative association between sPA and FT4 [β = -1.078, 95% confidence interval (CI): -1.729 to -0.427], as well as a positive relationship between sPA and FT3/FT4 ratio (β = 0.073, 95% CI: 0.044 to 0.102). These results did not change on multiple imputations. In the subgroup analyses, the associations were more significant in male and obese subjects. Conclusion: This investigation demonstrated the significant correlation between sPA and thyroid dysfunction, which suggested the close relationship between lipotoxicity and hypothyroidism or subclinical hypothyroidism. Future research is required to confirm these findings.
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