Evidence map›Paper›PMID 35592614›Full record

ReviewBiochemistry and biophysics reports2022

Key players in regulatory RNA realm of bacteria.

Gowthami Mahendran, Oshadhi T Jayasinghe, Dhanushika Thavakumaran, Gayan Mirihana Arachchilage, Gayathri N Silva

Abstract readReview
In one paragraph

Review in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. TheRNA (New York, N.Y.) · 2024
    Article
  4. Review
  5. Article
  6. RyhB in Avian PathogenicInternational journal of molecular sciences · 2022
    Article
  7. Prokaryotic ncRNAs: Master regulators of gene expression.Current research in pharmacology and drug discovery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gowthami MahendranDepartment of Chemistry, University of Colombo, Colombo, Sri Lanka.
Oshadhi T JayasingheDepartment of Chemistry, University of Colombo, Colombo, Sri Lanka.
Dhanushika ThavakumaranDepartment of Chemistry, University of Colombo, Colombo, Sri Lanka.
Gayan Mirihana ArachchilageHoward Hughes Medical Institute, Yale University, New Haven, CT, 06520-8103, USA.
Gayathri N SilvaDepartment of Chemistry, University of Colombo, Colombo, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise regulation of gene expression is crucial for living cells to adapt for survival in diverse environmental conditions. Among the common cellular regulatory mechanisms, RNA-based regulators play a key role in all domains of life. Discovery of regulatory RNAs have made a paradigm shift in molecular biology as many regulatory functions of RNA have been identified beyond its canonical roles as messenger, ribosomal and transfer RNA. In the complex regulatory RNA network, riboswitches, small RNAs, and RNA thermometers can be identified as some of the key players. Herein, we review the discovery, mechanism, and potential therapeutic use of these classes of regulatory RNAs mainly found in bacteria. Being highly adaptive organisms that inhabit a broad range of ecological niches, bacteria have adopted tight and rapid-responding gene regulation mechanisms. This review aims to highlight how bacteria utilize versatile RNA structures and sequences to build a sophisticated gene regulation network.

Indexed as

ncRNARegulatory RNAsRiboswitchRNA thermometersRNA

Identifiers

PMID35592614
PMCPMC9111926

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.