Evidence map›Paper›PMID 35592546›Full record

ArticleWellcome open research2022

The EWAS Catalog: a database of epigenome-wide association studies.

Thomas Battram, Paul Yousefi, Gemma Crawford, Claire Prince, Mahsa Sheikhali Babaei, Gemma Sharp, Charlie Hatcher, María Jesús Vega-Salas, Sahar Khodabakhsh, Oliver Whitehurst and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wellcome open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 31 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 31 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 31 syntheses or guidelines pooled it.

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  6. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
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128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Thomas BattramMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Paul YousefiMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Gemma CrawfordMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Claire PrinceMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Mahsa Sheikhali BabaeiMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Gemma SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Charlie HatcherMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
María Jesús Vega-SalasCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, BS8 1TH, UK.
Sahar KhodabakhshCentre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, BS8 1TH, UK.
Oliver WhitehurstBristol Medical School, University of Bristol, Bristol, BS8 1TH, UK.ORCID https://orcid.org/0000-0002-4575-2092
Ryan LangdonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Luke MahoneyBristol Medical School, University of Bristol, Bristol, BS8 1TH, UK.
Hannah R ElliottMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.ORCID https://orcid.org/0000-0002-1500-3533
Giulia MancanoMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Matthew A LeeMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.ORCID https://orcid.org/0000-0001-6262-3447
Sarah H WatkinsMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Abigail C LayBristol Renal, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0001-5923-634X
Gibran HemaniMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.ORCID https://orcid.org/0000-0003-0920-1055
Tom R GauntMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Caroline L ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
James R Staley *MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.
Matthew Suderman *MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 1TH, UK.

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/4Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/4Medical Research Council MR/S009310/1Medical Research Council MR/S036520/1Wellcome Trust
6 · The paper itself

Abstract

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation measures in population-based cohorts and case-control studies has resulted in a dramatic expansion of the number of EWAS being performed and published. To make this rich source of results more accessible, we have manually curated a database of CpG-trait associations (with p<1x10

Indexed as

ALSPACdatabaseepigeneticsepigenome-wideEWAS

Identifiers

PMID35592546
PMCPMC9096146.2

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.