Evidence map›Paper›PMID 35592516›Full record

ArticleJournal of the Endocrine Society2022

Variation in Glycemic Outcomes in Focal Forms of Congenital Hyperinsulinism-The UK Perspective.

Antonia Dastamani, Daphne Yau, Clare Gilbert, Kate Morgan, Paolo De Coppi, Ross J Craigie, Jamshed Bomanji, Lorenzo Biassoni, Rakesh Sajjan, Sarah E Flanagan and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Congenital Hyperinsulinism With Paternally InheritedJournal of the ASEAN Federation of Endocrine Societies · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Antonia DastamaniEndocrinology Department, Great Ormond Street Hospital for Children, London, UK.ORCID https://orcid.org/0000-0002-6332-3136
Daphne YauDepartment of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK.
Clare GilbertEndocrinology Department, Great Ormond Street Hospital for Children, London, UK.
Kate MorganEndocrinology Department, Great Ormond Street Hospital for Children, London, UK.
Paolo De CoppiDepartment of Surgery, Great Ormond Street Hospital for Children, London, UK.
Ross J CraigieDepartment of Paediatric Surgery, Royal Manchester Children's Hospital, Manchester, UK.
Jamshed BomanjiNuclear Medicine Department, UCL Hospitals NHS Foundation Trust, London, UK.
Lorenzo BiassoniNuclear Medicine Department, Great Ormond Street Hospital for Children, London, UK.
Rakesh SajjanNuclear Medicine Department, Royal Manchester Children's Hospital, Manchester, UK.
Sarah E FlanaganInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Jayne A L HoughtonInstitute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Senthil SenniappanDepartment of Paediatric Endocrinology, Alder Hey Children's Hospital NHS Trust, Liverpool, UK.
Mohammed DidiDepartment of Paediatric Endocrinology, Alder Hey Children's Hospital NHS Trust, Liverpool, UK.
Mark J DunneSchool of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Indraneel BanerjeeDepartment of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK.ORCID https://orcid.org/0000-0003-4280-7470
Pratik ShahEndocrinology Department, Great Ormond Street Hospital for Children, London, UK.ORCID https://orcid.org/0000-0002-4402-8297
Great Ormond Street Hospital · GBRoyal Manchester Children's Hospital · GBUniversity of Exeter · GBUniversity of Liverpool · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: In focal congenital hyperinsulinism (CHI), localized clonal expansion of pancreatic β-cells causes excess insulin secretion and severe hypoglycemia. Surgery is curative, but not all lesions are amenable to surgery. Objective: We describe surgical and nonsurgical outcomes of focal CHI in a national cohort. Methods: Patients with focal CHI were retrospectively reviewed at 2 specialist centers, 2003-2018. Results: Of 59 patients with focal CHI, 57 had heterozygous mutations in Conclusion: Despite a unifying genetic basis of disease, we report inherent heterogeneity in focal CHI patients impacting outcomes of both surgical and medical management.

Indexed as

ABCC8 genefocal lesionhyperinsulinemic hypoglycemia

Identifiers

PMID35592516
PMCPMC9113085
OpenAlexW4220826034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.