Evidence map›Paper›PMID 35592326›Full record

ArticleFrontiers in immunology2022

Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus.

Alexander Stewart, Emma Sinclair, Joseph Chi-Fung Ng, Joselli Silva O'Hare, Audrey Page, Ilaria Serangeli, Christian Margreitter, Federica Orsenigo, Katherine Longman, Cecile Frampas and 13 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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  4. Revised Adaptive Immune Receptor Data in the Immune Epitope Database.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 8 institutions in 2 countries.

Alexander StewartSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Emma SinclairSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Joseph Chi-Fung NgRandall Centre for Cell & Molecular Biophysics, King's College London, London, United Kingdom.
Joselli Silva O'HareSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Audrey PageFaculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Ilaria SerangeliDipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, Rome, Italy.
Christian MargreitterDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Federica OrsenigoSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Katherine LongmanDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Cecile FrampasDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Catia CostaDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Holly-May LewisDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Nora KasarSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Bryan WuFaculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
David KiplingSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
Peter Jm OpenshawFaculty of Medicine, Imperial College London, London, United Kingdom.
Christopher ChiuFaculty of Medicine, Imperial College London, London, United Kingdom.
J Kenneth BaillieRoslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
Janet T ScottMRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom.
Malcolm G SempleFaculty of Health & Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Melanie J BaileyDepartment of Chemistry, University of Surrey, Guildford, United Kingdom.
Franca FraternaliRandall Centre for Cell & Molecular Biophysics, King's College London, London, United Kingdom.
Deborah K Dunn-WaltersSchool of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom.
University of Surrey · GBKing's College London · GBImperial College London · GBMRC University of Glasgow Centre for Virus Research · GBSapienza University of Rome · ITUniversity of Edinburgh · GBUniversity of Liverpool · GBUniversity of Milano-Bicocca · IT

Funding

Medical Research Council G0902266Medical Research Council MC_G1001212Medical Research Council MC_PC_19025Medical Research Council MC_PC_19026Medical Research Council MR/L01257X/1Medical Research Council MR/L01257X/2Medical Research Council MR/R005982/1Medical Research Council MR/R502121/1Medical Research Council MR/T50256X/1
6 · The paper itself

Abstract

Immunoglobulin gene heterogeneity reflects the diversity and focus of the humoral immune response towards different infections, enabling inference of B cell development processes. Detailed compositional and lineage analysis of long read IGH repertoire sequencing, combining examples of pandemic, epidemic and endemic viral infections with control and vaccination samples, demonstrates general responses including increased use of

Indexed as

COVID-19EbolavirusHemorrhagic Fever, EbolaRespiratory Syncytial Virus, HumanAntibodies, ViralHumansPandemicsSARS-CoV-2Antibodies, ViralB cellclass-switch recombination (CSR)COVID-19ebolaimmunityrepertoireRSV (respiratory syncytial virus)

Identifiers

PMID35592326
PMCPMC9111746
OpenAlexW4225421533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.