SynthesisFrontiers in neuroscience2022
Early Life Sleep Deprivation and Brain Development: Insights From Human and Animal Studies.
Synthesis in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between sleep consolidation and growth and development in early childhood: A systematic review.Health promotion perspectives · 2024Pooled it
- Agomelatine augmentation of sertraline in the treatment of moderate to severe obsessive-compulsive disorder: a randomized double-blinded placebo-controlled clinical trial.BMC psychiatry · 2023Trial
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity.Nutrients · 2026Review
- Sleep and development in cerebral palsy.Pediatric research · 2026Article
- Shorter sleep, higher odds: a nationally representative analysis of the dose-dependent link to depression among 48.8 million U.S. youth.Frontiers in pediatrics · 2026Article
- From Cradle to Early-Life Sleep: A Bibliometric Analysis of Global Research on Neonatal Sleep.Nature and science of sleep · 2026Article
- Association Between Age-Specific Sleep Sufficiency and Autism Spectrum Disorder in U.S. Children.Journal of autism and developmental disorders · 2025Article
- Associations between gestational polybrominated diphenyl ether (PBDE) serum concentrations and child sleep outcomes from ages 2-8 years.Environmental research · 2025Article
- Associations Between REM Sleep-like Posture Expression and Cognitive Flexibility in 2-Month-Old Japanese Black Calves.Animals : an open access journal from MDPI · 2025Article
- Sleep Disturbances and Disorders in Children and Adolescents with Cerebral Palsy: A Narrative Review.Journal of clinical medicine · 2025Review
- Concussion Disrupts Sleep in Adolescents: A Systematic Review and Meta-Analysis.Clocks & sleep · 2025Review
- Article
- SLEEP-WAKE: A Comprehensive Mnemonic for Systematic Screening of Sleep-Related Issues.Pediatric discovery · 2025Article
- A Novel Ashwagandha (Biomolecules · 2025Article
- The importance of sleep for the developing brain.Current sleep medicine reports · 2024Article
- Electroacupuncture inhibits hippocampal oxidative stress and autophagy in sleep-deprived rats through the protein kinase B and mechanistic target of rapamycin signaling pathway.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- The role of sleep disturbances in associations between early life adversity and subsequent brain and language development during childhood.Frontiers in sleep · 2024Article
- The Function of Sleep and the Treatment of Primary Insomnia.Deutsches Arzteblatt international · 2023Review
- The Impact of Growth Hormone Therapy on Sleep-Related Health Outcomes in Children with Prader-Willi Syndrome: A Review and Clinical Analysis.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adequate sleep especially during developmental stages of life, is considered essential for normal brain development and believed to play an important role in promoting healthy cognitive and psychosocial development, while persistent sleep disturbances and/or sleep deprivation during early life are believed to trigger many mental ailments such as anxiety disorders, depression, and cognitive impairment. Initially it was suggested that adverse mental health conditions adversely affect sleep, however, it is now accepted that this association is bidirectional. In fact, sleep disturbances are listed as a symptom of many mental health disorders. Of special interest is the association between early life sleep deprivation and its negative mental health outcomes. Studies have linked persistent early life sleep deprivation with later life behavioral and cognitive disturbances. Neurobiological underpinnings responsible for the negative outcomes of early life sleep deprivation are not understood. This is a significant barrier for early therapeutic and/or behavioral intervention, which can be feasible only if biological underpinnings are well-understood. Animal studies have provided useful insights in this area. This article focusses on the knowledge gained from the research conducted in the area of early life sleep deprivation, brain development, and behavioral function studies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.