Evidence map›Paper›PMID 35592121›Full record

ArticleFrontiers in surgery2022

Changes in Indices of Steatosis and Fibrosis in Liver Grafts of Living Donors After Weight Reduction.

Jaehyuk Choi, YoungRok Choi, Su Young Hong, Sanggyun Suh, Kwangpyo Hong, Eui Soo Han, Jeong-Moo Lee, Suk Kyun Hong, Nam-Joon Yi, Kwang-Woong Lee and 1 more

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Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jaehyuk ChoiDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
YoungRok ChoiDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Su Young HongDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Sanggyun SuhDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Kwangpyo HongDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Eui Soo HanDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Jeong-Moo LeeDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Suk Kyun HongDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Nam-Joon YiDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Kwang-Woong LeeDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Kyung-Suk SuhDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Seoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A short-term weight reduction program for potential living donors was introduced to reduce the extent of hepatic steatosis prior to liver transplantation. We aimed to investigate changes in non-invasive hepatic steatosis and fibrosis indices among those who completed the program. Methods: Among 1,950 potential living liver donors between January 2011 and May 2019, 160 living donors joined the weight reduction program. The prospectively collected clinical data of these potential liver donors were analyzed retrospectively. Hepatic steatosis and fibrosis scores were determined using the fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD fibrosis score (NFS) and compared to MR spectroscopy (MRS) fat fraction results before and after weight reduction. Results: Thirty-nine potential living donors who had undergone MRS both before and after weight reduction were included in the analysis. Their body weight decreased from 78.02 ± 10.89 kg to 72.36 ± 10.38 kg over a mean of 71.74 ± 58.11 days. FLI, HSI, and MRS values decreased significantly from 41.52 ± 19.05 to 24.53 ± 15.93, 39.64 ± 3.74 to 35.06 ± 3.82, and 12.20 ± 4.05 to 6.24 ± 3.36, respectively. No significant decreases in NFS were observed. There was a significant correlation between the extent of HSI change and the extent of MRS change (R Conclusion: The weight reduction program significantly improved non-invasive indices of hepatic steatosis over a short period. HSI may allow for prediction of simple decreases in hepatic steatosis.

Indexed as

fatty liverhepatic fibrosishepatic steatosisliving donorNAFLDweight loss

Identifiers

PMID35592121
PMCPMC9110767
OpenAlexW4225391187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.