Evidence map›Paper›PMID 35591182›Full record

ReviewSensors (Basel, Switzerland)2022

The Role of Different Retinal Imaging Modalities in Predicting Progression of Diabetic Retinopathy: A Survey.

Mohamed Elsharkawy, Mostafa Elrazzaz, Ahmed Sharafeldeen, Marah Alhalabi, Fahmi Khalifa, Ahmed Soliman, Ahmed Elnakib, Ali Mahmoud, Mohammed Ghazal, Eman El-Daydamony and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Diabetic Retinopathy-A Review.Current diabetes reviews · 2025
    Review
  14. Gold Nanoparticles for Retinal Molecular Optical Imaging.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Mohamed ElsharkawyBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-9242-9709
Mostafa ElrazzazBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-8842-418X
Ahmed SharafeldeenBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0002-6838-8211
Marah AlhalabiElectrical, Computer and Biomedical Engineering Department, College of Engineering, Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates.ORCID 0000-0001-8190-5263
Fahmi KhalifaBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0003-3318-2851
Ahmed SolimanBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0002-1931-3416
Ahmed ElnakibBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-6084-3622
Ali MahmoudBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0003-2557-9699
Mohammed GhazalElectrical, Computer and Biomedical Engineering Department, College of Engineering, Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates.ORCID 0000-0002-9045-6698
Eman El-DaydamonyInformation Technology Department, Faculty of Computers and Information, Mansoura University, Mansoura 35516, Egypt.
Ahmed AtwanInformation Technology Department, Faculty of Computers and Information, Mansoura University, Mansoura 35516, Egypt.
Harpal Singh SandhuBioengineering Department, University of Louisville, Louisville, KY 40292, USA.
Ayman El-BazBioengineering Department, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-7264-1323
University of Louisville · USAbu Dhabi University · AEMansoura University · EG

Funding

Abu Dhabi's Advanced Technology Research Council AARE19-143ASPIRE ASPIRE Award for Research Excellence 2019 under the Advanced Technology Research Council
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a devastating condition caused by progressive changes in the retinal microvasculature. It is a leading cause of retinal blindness in people with diabetes. Long periods of uncontrolled blood sugar levels result in endothelial damage, leading to macular edema, altered retinal permeability, retinal ischemia, and neovascularization. In order to facilitate rapid screening and diagnosing, as well as grading of DR, different retinal modalities are utilized. Typically, a computer-aided diagnostic system (CAD) uses retinal images to aid the ophthalmologists in the diagnosis process. These CAD systems use a combination of machine learning (ML) models (e.g., deep learning (DL) approaches) to speed up the diagnosis and grading of DR. In this way, this survey provides a comprehensive overview of different imaging modalities used with ML/DL approaches in the DR diagnosis process. The four imaging modalities that we focused on are fluorescein angiography, fundus photographs, optical coherence tomography (OCT), and OCT angiography (OCTA). In addition, we discuss limitations of the literature that utilizes such modalities for DR diagnosis. In addition, we introduce research gaps and provide suggested solutions for the researchers to resolve. Lastly, we provide a thorough discussion about the challenges and future directions of the current state-of-the-art DL/ML approaches. We also elaborate on how integrating different imaging modalities with the clinical information and demographic data will lead to promising results for the scientists when diagnosing and grading DR. As a result of this article's comparative analysis and discussion, it remains necessary to use DL methods over existing ML models to detect DR in multiple modalities.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaFluorescein AngiographyHumansRetinaTomography, Optical Coherencecomputer-aided diagnostic system (CAD)deep learning (DL)diabetic retinopathy (DR)fundus photography (FP)machine learning (ML)OCT angiography (OCTA)optical coherence tomography (OCT)

Identifiers

PMID35591182
PMCPMC9101725
OpenAlexW4229059038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.