Evidence map›Paper›PMID 35590379›Full record

ReviewCell & bioscience2022

Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases.

Zonghan Liu, Yi Sun, Zhengtang Qi, Lu Cao, Shuzhe Ding

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Therapeutic Potential of Mitochondrial Transplantation with Focus on DBD.International journal of molecular sciences · 2026
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zonghan LiuSchool of Physical Education & Health Care, East China Normal University, Shanghai, China.
Yi SunSchool of Physical Education & Health Care, East China Normal University, Shanghai, China.
Zhengtang QiSchool of Physical Education & Health Care, East China Normal University, Shanghai, China.
Lu CaoSchool of Physical Education & Health Care, East China Normal University, Shanghai, China.
Shuzhe DingSchool of Physical Education & Health Care, East China Normal University, Shanghai, China. szding@tyxx.ecnu.edu.cn.ORCID http://orcid.org/0000-0001-6466-7427

Funding

National Natural Science Foundation of China 31600967National Natural Science Foundation of China 31671241The Key Laboratory Construction Project of Adolescent Health Assessment and Exercise Intervention of the Ministry of Education 11000-30190-513300/006
6 · The paper itself

Abstract

Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. In recent years, the phenomenon of mitochondrial transfer has attracted significant attention and interest from biologists and medical investigators. Intercellular mitochondrial transfer occurs in different ways, including tunnelling nanotubes (TNTs), extracellular vesicles (EVs), and gap junction channels (GJCs). According to research on intercellular mitochondrial transfer in physiological and pathological environments, mitochondrial transfer hold great potential for maintaining body homeostasis and regulating pathological processes. Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed.

Indexed as

AgeingCancer therapyEnergy metabolismMitochondrial transferMitochondrial transplantationmtDNA mutations and deletionsStem cellTissue injury

Identifiers

PMID35590379
PMCPMC9121600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.