Evidence map›Paper›PMID 35590223›Full record

ArticleMed (New York, N.Y.)2021

Fatty liver progression and carcinogenesis: Beware of pathogenic T cells.

Petra Hirsova, Gregory J Gores

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Med (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Do autoantigens drive MASH progression?Hepatology (Baltimore, Md.) · 2025
    Article
  2. Article
  3. The Role of CD4International journal of molecular sciences · 2024
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Petra HirsovaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Gregory J GoresDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address: gores.gregory@mayo.edu.
Mayo Clinic in Arizona · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI Rory Smoot · 2018 to 2026
$20.5M
NCI NIH HHS P50 CA210964NIDDK NIH HHS P30 DK084567
6 · The paper itself

Abstract

The pathogenesis of nonalcoholic steatohepatitis (NASH) and NASH-related liver cancer is incompletely understood. In the recent issue of Nature, two studies by Dudek et al. and Pfister et al. revealed the critical role of CD8 T cells in instigating liver damage and promoting liver cancer in NASH.

Indexed as

Liver NeoplasmsNon-alcoholic Fatty Liver DiseaseCarcinogenesisCD8-Positive T-LymphocytesHumansLymphocyte Count

Identifiers

PMID35590223
OpenAlexW3163357908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.