Evidence map›Paper›PMID 35590164›Full record

ArticleMed (New York, N.Y.)2021

Tuning in to inflammation: A path forward for precise and efficacious microbiome medicines?

Sathish Subramanian, Ramnik J Xavier

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Med (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sathish SubramanianDepartment of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Broad Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbes sense various external cues, including those found in inflammatory conditions, yielding possibilities for connecting sensory circuits to effector pathways to engineer precise and scaled interventions to target pathway activity. Scott et al. combined directed evolution and a synthetic gene circuit in yeast to fine-tune sensing of extracellular ATP, showing promise as a live therapeutic in two murine models of chemical colitis and a murine model of antibody-mediated enteritis.

Indexed as

ColitisEnteritisMicrobiotaAnimalsInflammationMiceTime

Identifiers

PMID35590164
OpenAlexW3195155950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.