Evidence map›Paper›PMID 35590136›Full record

ArticleMed (New York, N.Y.)2021

Acetylated tau: A missing link between head injury and dementia.

Zhen Zhao, Berislav V Zlokovic

Abstract readComment
PubMed Publisher
In one paragraph

Article in Med (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Zhen ZhaoDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: zzhao@usc.edu.
Berislav V ZlokovicDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: zlokovic@usc.edu.

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrierR01NS034467 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 1995 to 2024
$9.1M
The role of pericytes in white matter diseaseR01NS100459 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2016 to 2020
$3.6M
Activated protein C system in stroke modelsR01NS090904 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2014 to 2018
$3.2M
Cerebrovascular beta-Amyloidosis: A-beta CNS Transport PathwaysR01AG023084 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2015 to 2019
$3.0M
A TIMEM252-dependent Microvascular Endophenotype in Alzheimer’s DiseaseRF1NS122060 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2021 to 2021
$2.3M
Zika Virus Capsid Protein Mediated Blockage of host microRNA machineryR01NS110687 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2023
$2.2M
Pericyte-neuronal crosstalk in health and Alzheimer's DiseaseR01AG061288 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2023
$2.1M
The role of pericytes in the adult and the aging brainR01AG039452 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2011 to 2015
$1.6M
The molecular mechanism of PICALM-dependent endosomal traffickingR21AG066090 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2020
$454k
Genetic interaction of PICALM and APOE in Alzheimer's diseaseR03AG063287 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2020
$330k
NIA NIH HHS P01 AG052350NIA NIH HHS R01 AG023084NIA NIH HHS R01 AG039452NIA NIH HHS R01 AG061288NIA NIH HHS R03 AG063287NIA NIH HHS R21 AG066090NINDS NIH HHS R01 NS034467NINDS NIH HHS R01 NS090904NINDS NIH HHS R01 NS100459NINDS NIH HHS R01 NS110687NINDS NIH HHS RF1 NS122060
6 · The paper itself

Abstract

Head injury is the most significant environmental risk factor for Alzheimer's disease and dementia. Yet, our understanding of its pathophysiology remains limited, and therapeutic targets remain elusive. In a recent issue of Cell, Shin et al. discovered a promising molecular pathway linking head injury to Alzheimer's disease.

Indexed as

Alzheimer DiseaseCraniocerebral TraumaHumanstau Proteinstau Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.