ArticleScientific reports2022
Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Basaloid-Solid Adenoid Cystic Carcinoma of the Breast: A Case Report and Literature Review.Case reports in pathology · 2026Article
- Photodynamic therapy with local-targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12-year survival: A case report.Oncology letters · 2026Article
- The effect of adjuvant radiotherapy on M0 adenoid cystic carcinoma of the breast: a retrospective cohort study based on SEER data.Gland surgery · 2025Article
- Seven Shades of Triple Negativity: A Review Unveiling the Low-Grade Spectrum of Breast Cancer.Cancers · 2025Review
- Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature.Oncology letters · 2025Article
- Analysis of clinicopathological features and clinical significance in 25 cases of mammary adenoid cystic carcinoma.BMC women's health · 2025Article
- Solid-Basaloid Adenoid Cystic Carcinoma of the Ipsilateral Breast Remnant in Postoperative Luminal HER2-Type Breast Cancer: A Case Report.Surgical case reports · 2025Article
- Optimal surgical procedure for treating early-stage adenoid cystic carcinoma of the breast.Scientific reports · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenoid cystic carcinoma (AdCC) of the breast is a rare indolent carcinoma of salivary gland-type tumors, frequently associated with MYB genetic alteration. Solid and basaloid adenoid cystic carcinoma (SB-AdCC) is considered a sparse variant of AdCC. This study sought to search for clinicopathological and genomic features in SB-AdCC. Registered clinicopathological data on a cohort of 13 AdCC of the breast cases, including six conventional adenoid cystic carcinoma (C-AdCC) cases and seven SB-AdCC cases, were collected. MYB gene rearrangement via fluorescent in situ hybridization was investigated and MYB protein expression was evaluated by immunohistochemistry. Compared with C-AdCC, we found that the distribution of SB-AdCC cases were shifted to older age and were more frequently distant metastasis. Moreover, metastasis cases also showed a high (exceed 30%) Ki-67 index. Both groups showed MYB rearrangements and MYB protein expression, but they were less frequent in SB-AdCC than C-AdCC. To conclude, our results suggest that SB-AdCC is an aggressive variant of mammary AdCC with a higher incidence of distant metastases compared with C-AdCC, though they share common molecular features. A high Ki-67 index may be an adverse prognostic factor for metastasis.
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