SynthesisInternational journal of obesity (2005)2022
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.
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Synthesis in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
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32 citing papers in PubMed, 41 citations in OpenAlex.
- ACE2 downregulation contributes to adverse cardiovascular and reproductive outcomes in female mice on high-fat diet.American journal of physiology. Heart and circulatory physiology · 2026Article
- GANomics: bridging legacy and modern transcriptomic platforms for clinical applications.NPJ genomic medicine · 2026Article
- Association of Body Mass Index with SARS-CoV-2 Infection in Inflammatory Arthritis Patients Receiving Biologic Therapy: Singapore National Biologics Register Findings.International journal of rheumatic diseases · 2026Article
- Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update.Obesity (Silver Spring, Md.) · 2026Review
- Genetic regulation of fatty acid content in adipose tissue.American journal of human genetics · 2026Article
- Impact of Obesity and Ageing on the Expression of Key Mediators of SARS-CoV-2 Infection in Human Adipose Tissue.International journal of molecular sciences · 2025Article
- Molecular dissection of the role of ACE2 in glucose homeostasis.Physiological reviews · 2025Review
- Diabetic cardiomyopathy and COVID-19: intersecting pathways and amplified cardiovascular risk.Frontiers in pharmacology · 2025Review
- Genetic effects on the skin methylome in healthy older twins.American journal of human genetics · 2024Article
- The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19.International journal of molecular sciences · 2024Review
- Article
- Food-Derived Up-Regulators and Activators of Angiotensin Converting Enzyme 2: A Review.Journal of agricultural and food chemistry · 2024Review
- New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review.International journal of molecular sciences · 2024Review
- Unveiling risk factors for post-COVID-19 syndrome development in people with type 2 diabetes.Frontiers in endocrinology · 2024Article
- Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2.Journal of virology · 2023Article
- A network meta-analysis of association between cardiometabolic risk factors and COVID-19 outcome severity.Journal of diabetes · 2023Article
- Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.bioRxiv : the preprint server for biology · 2023Article
- Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases.Cardiology discovery · 2023Article
- Lung Epithelial Cells from Obese Patients Have Impaired Control of SARS-CoV-2 Infection.International journal of molecular sciences · 2023Article
- Reduction in Serum Magnesium Levels and Renal Function Are Associated with Increased Mortality in Obese COVID-19 Patients.Nutrients · 2022Article
Corrections and comments
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Authors and funding
36 authors at 7 institutions in 4 countries.
Julia S El-Sayed Moustafa *Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. julia.el-sayed_moustafa@kcl.ac.uk.ORCID 0000-0001-6963-6654
Anne U Jackson *Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9672-2547
Sarah M Brotman *Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7566-8895
Li Guan *Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Sergio VillicañaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2455-7095
Amy L RobertsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Antonino ZitoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0003-1931-984X
Lori BonnycastleNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Michael R ErdosNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Narisu NarisuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2991-6392
Ryan WelchDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Tingfen YanNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Timo LakkaInstitute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-9199-2871
Stephen ParkerDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Jaakko TuomilehtoUniversity of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.
Jeffrey SeowDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Carl GrahamDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Isabella HuettnerDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Sam AcorsDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Neophytos KouphouDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Samuel WadgeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Emma L DuncanDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Claire J StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Katie J DooresDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.
Michael H MalimDepartment of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK.ORCID 0000-0002-7699-2064
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Päivi PajukantaDepartment of Human Genetics and Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6442-7754
Heikki A KoistinenUniversity of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-7870-070X
Markku LaaksoDepartment of Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3394-7749
Mario FalchiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-5646-1004
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-3858-5986
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-6721-153X
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK. kerrin.small@kcl.ac.uk.ORCID 0000-0003-4566-0005
King's College London · GBUniversity of Michigan · USNational Institutes of Health · USUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · USHarvard University · US
Funding
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVIS, RICHARD C · 1985 to 2019
$50.2MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MNRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9MIntramural NIH HHS ZIA HG000024Medical Research Council MR/L01999X/1Medical Research Council MR/M004422/1Medical Research Council MR/R023131/1NHLBI NIH HHS P01 HL028481NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIGMS NIH HHS T32 GM007092Wellcome Trust 221574
Abstract
backgroundCOVID-19 severity varies widely. Although some demographic and cardio-metabolic factors, including age and obesity, are associated with increasing risk of severe illness, the underlying mechanism(s) are uncertain. SUBJECTS/
methodsIn a meta-analysis of three independent studies of 1471 participants in total, we investigated phenotypic and genetic factors associated with subcutaneous adipose tissue expression of Angiotensin I Converting Enzyme 2 (ACE2), measured by RNA-Seq, which acts as a receptor for SARS-CoV-2 cellular entry.
resultsLower adipose tissue ACE2 expression was associated with multiple adverse cardio-metabolic health indices, including type 2 diabetes (T2D) (P = 9.14 × 10
conclusionsOur results demonstrate that individuals with cardio-metabolic features known to increase risk of severe COVID-19 have lower background ACE2 levels in this highly relevant tissue. Reduced adipose tissue ACE2 expression may contribute to the pathophysiology of cardio-metabolic diseases, as well as the associated increased risk of severe COVID-19.
Indexed as
Adipose TissueAngiotensin-Converting Enzyme 2COVID-19Cardiometabolic Risk FactorsDiabetes Mellitus, Type 2Endothelial CellsHumansObesitySARS-CoV-2Angiotensin-Converting Enzyme 2
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