Evidence map›Paper›PMID 35589962›Full record

Observational studyInternational journal of obesity (2005)2022

In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.

Wanyu Huang, Tak Igusa, Guoying Wang, Jessie P Buckley, Xiumei Hong, Eric Bind, Andrew Steffens, Jhindan Mukherjee, Douglas Haltmeier, Yuelong Ji and 4 more

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03228875 (Early Life Origins of Pediatric and Adult Diseases), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03228875 recruitingnot on this map

Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study

Typeobservational_patient_registrySponsorJohns Hopkins Bloomberg School of Public HealthRan1998 to 2028Enrolled24,000ConditionsMaternal Health, Child Health, Pregnancy Complications, Birth Outcome, Adverse
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Wanyu HuangDepartment of Civil and Systems Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA.ORCID 0000-0002-7276-5892
Tak IgusaDepartment of Civil and Systems Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA. tigusa1@jhu.edu.
Guoying WangCenter on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Jessie P BuckleyDepartment of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Xiumei HongCenter on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Eric BindNew Jersey Department of Health, Environmental and Chemical Laboratory Services, Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.ORCID 0000-0003-3074-2833
Andrew SteffensNew Jersey Department of Health, Environmental and Chemical Laboratory Services, Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
Jhindan MukherjeeNew Jersey Department of Health, Environmental and Chemical Laboratory Services, Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
Douglas HaltmeierNew Jersey Department of Health, Environmental and Chemical Laboratory Services, Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
Yuelong JiCenter on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Richard XuDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Wenpin HouDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Zhihua Tina FanNew Jersey Department of Health, Environmental and Chemical Laboratory Services, Metals Laboratory, P. O. Box 360, Trenton, NJ, USA.
Xiaobin WangCenter on Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. xwang82@jhu.edu.ORCID 0000-0003-4451-302X
Johns Hopkins University · USNew Jersey Department of Health · US

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth CohortR01HD086013 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LEE, BRUCE Y, WANG, XIAOBIN · 2016 to 2020
$3.3M
Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth CohortR01HD098232 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LIANG, LIMING, WANG, XIAOBIN · 2019 to 2022
$2.7M
Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
Maternal Exposure to Low Level Mercury, Metabolome, and Child Cardiometabolic Risk in Multi-Ethnic Prospective Birth CohortsR01ES031272 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, GUOYING, WANG, XIAOBIN · 2020 to 2024
$1.2M
Molecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562k
Epigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354k
In Utero Exposure to Metals and Vitamins B on Placenta and Child Cardiometabolic OutcomesR03ES029594 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, GUOYING · 2019 to 2020
$164k
NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD086013NICHD NIH HHS R01 HD098232NICHD NIH HHS R21 HD066471NIEHS NIH HHS R01 ES031272NIEHS NIH HHS R01 ES031521NIEHS NIH HHS R03 ES029594NIEHS NIH HHS R21 ES011666
6 · The paper itself

Abstract

BACKGROUND/

objectivesLow-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective. SUBJECTS/

methodsThis study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.

resultsIn this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.

conclusionsIn this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE WHERE IT WAS OBTAINED: NCT03228875.

Indexed as

MetalsMicronutrientsPediatric ObesityPrenatal Exposure Delayed EffectsAdolescentBayes TheoremCadmiumChildChild, PreschoolFemaleFolic AcidHumansInfantInfant, NewbornLeadMercuryCadmiumFolic AcidLeadMercuryMetalsMicronutrients

Identifiers

PMID35589962
PMCPMC9329205
OpenAlexW4280499559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.