Trial reportJournal of clinical monitoring and computing2022
Evaluation of indigenously developed closed-loop automated blood pressure control system (claps): a preliminary study.
Trial report in Journal of clinical monitoring and computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of closed-loop systems for intravenous drug administration: a systematic review and meta-analysis of randomised controlled trials.Journal of clinical monitoring and computing · 2024Pooled it
- Monitoring Inputs, Control Architectures, and Failure Modes in Closed-Loop Vasopressor Systems: A Comprehensive Review.Sensors (Basel, Switzerland) · 2026Review
- Goal-directed therapy: what is the goal again?Perioperative medicine (London, England) · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Closed-loop systems have been designed to assist anesthetists in controlling anesthetic drugs and also maintaining the stability of various physiological variables in the normal range. In the present study, we describe and clinically evaluated a novel closed-loop automated blood pressure control system (CLAPS) in patients undergoing cardiac surgery under cardiopulmonary bypass. Forty ASA II-IV adult patients undergoing elective cardiac surgery were randomly allocated to receive adrenaline, noradrenaline, phenylephrine and nitroglycerine (NTG) adjusted either through CLAPS (CLAPS group) or manually (Manual group). The desired target mean arterial blood pressure (MAP) for each patient in both groups was set by the attending anesthesiologist. The hemodynamic performance was assessed based on the percentage duration of time the MAP remained within 20% of the set target. Automated controller performances were compared using performance error criteria of Varvel (MDPE, MDAPE, Wobble) and Global Score. MAP was maintained a significantly longer proportion of time within 20% of the target in the CLAPS group (79.4% vs. 65.5% p < 0.001, 't' test) as compared to the manual group. Median absolute performance error, wobble, and Global score was significantly lower in the CLAPS group. Hemodynamic stability was achieved with a significantly lower dose of Phenyepherine in the CLAPS group (1870 μg vs. 5400 μg, p < 0.05, 't' test). The dose of NTG was significantly higher in the CLAPS group (3070 μg vs. 1600 μg, p-value < 0.05, 't' test). The cardiac index and left ventricular end-diastolic area were comparable between the groups. Automated infusion of vasoactive drugs using CLAPS is feasible and also better than manual control for controlling hemodynamics during cardiac surgery. Trial registration number and date This trial was registered in the Clinical Trial Registry of India under Registration Number CTRI/2018/01/011487 (Retrospective; registration date; January 23, 2018).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.