ArticleNature communications2022
C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 59 citations in OpenAlex.
- Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity.PLoS computational biology · 2026Article
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- PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons inGenes & development · 2026Article
- Excitatory GABA receptors shape locomotor circuit organization in C. elegans.Scientific reports · 2026Article
- Generation of biophysical neuron model parameters from recorded electrophysiological responses.eLife · 2025Article
- PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons ofbioRxiv : the preprint server for biology · 2025Article
- Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.Science advances · 2025Article
- Decomposed Linear Dynamical Systems (dLDS) models reveal instantaneous, context-dependent dynamic connectivity in C. elegans.Communications biology · 2025Article
- Article
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- Review
- Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells.PLoS computational biology · 2025Article
- A leak KPNAS nexus · 2024Article
- C. elegans foraging as a model for understanding the neuronal basis of decision-making.Cellular and molecular life sciences : CMLS · 2024Review
- A tonically active master neuron modulates mutually exclusive motor states at two timescales.Science advances · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.PloS one · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- UBR-1 ubiquitin ligase regulates the balance between GABAergic and glutamatergic signaling.EMBO reports · 2023Article
- A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments.Neuroscience and biobehavioral reviews · 2023Review
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C. elegans neurons were thought to be non-spiking until our recent discovery of action potentials in the sensory neuron AWA; however, the extent to which the C. elegans nervous system relies on analog or digital coding is unclear. Here we show that the enteric motor neurons AVL and DVB fire synchronous all-or-none calcium-mediated action potentials following the intestinal pacemaker during the rhythmic C. elegans defecation behavior. AVL fires unusual compound action potentials with each depolarizing calcium spike mediated by UNC-2 followed by a hyperpolarizing potassium spike mediated by a repolarization-activated potassium channel EXP-2. Simultaneous behavior tracking and imaging in free-moving animals suggest that action potentials initiated in AVL propagate along its axon to activate precisely timed DVB action potentials through the INX-1 gap junction. This work identifies a novel circuit of spiking neurons in C. elegans that uses digital coding for long-distance communication and temporal synchronization underlying reliable behavioral rhythm.
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