ArticleNature communications2022
Topography-induced large-scale antiparallel collective migration in vascular endothelium.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- A Microfabricated Branch Selection Platform for Quantitative Measurement of Leader-Follower Interaction Strength and Interaction Range in Collective Cell Migration.Micromachines · 2026Article
- Micropatterning transcriptionally and phenotypically reprograms endothelial cells.Acta biomaterialia · 2026Article
- Mathematical Prediction for Geometry-Mediated Cell 3D In-Growth on Bone Tissue Engineering Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A novel method for evaluating and visualizing scratch wound healing assays using level-set and image sector analysis.PNAS nexus · 2025Article
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Unlocking the therapeutic potential of cellular mechanobiology.Science advances · 2025Review
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Cellular Signaling at the Nano-Bio Interface: Spotlighting Membrane Curvature.Annual review of physical chemistry · 2025Review
- Micro-Scale Topography Triggers Dynamic 3D Nuclear Deformations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization.Nature communications · 2025Article
- Confined cell migration along extracellular matrix space in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Strings and topological defects govern ordering kinetics in endothelial cell layers.Nature physics · 2025Article
- Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.PLoS computational biology · 2025Article
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- Electrowriting patterns and electric field harness directional cell migration for skin wound healing.Materials today. Bio · 2024Article
- Enhancing angiogenesis in peri-implant soft tissue with bioactive silk fibroin microgroove coatings on zirconia surfaces.Regenerative biomaterials · 2024Article
- Migration and division in cell monolayers on substrates with topological defects.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Fucoidan and topography modification improvedBioactive materials · 2023Article
- Self-curling 3D oriented scaffolds from fish scales for skeletal muscle regeneration.Biomaterials research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective migration of vascular endothelial cells is central for embryonic development, angiogenesis, and wound closure. Although physical confinement of cell assemblies has been shown to elicit specific patterns of collective movement in various cell types, endothelial migration in vivo often occurs without confinement. Here we show that unconfined endothelial cell monolayers on microgroove substrates that mimic the anisotropic organization of the extracellular matrix exhibit a specific type of collective movement that takes the form of a periodic pattern of antiparallel cell streams. We further establish that the development of these streams requires intact cell-cell junctions and that stream sizes are particularly sensitive to groove depth. Finally, we show that modeling the endothelial cell sheet as an active fluid with the microgrooves acting as constraints on cell orientation predicts the occurrence of the periodic antiparallel cell streams as well as their lengths and widths. We posit that in unconfined cell assemblies, physical factors that constrain or bias cellular orientation such as anisotropic extracellular matrix cues or directed flow-derived shear forces dictate the pattern of collective cell movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.