ArticleScientific reports2022
Integrated analysis of an in vivo model of intra-nasal exposure to instilled air pollutants reveals cell-type specific responses in the placenta.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.Journal of environmental health science & engineering · 2026Review
- Polycyclic aromatic hydrocarbons (PAHs) contribute to inflammation in a pregnancy cohort.Environmental research, health : ERH · 2026Article
- Prenatal exposure to particulate matter impairs offspring behavior via hippocampal NMDA receptor reduction: an in vivo and ex vivo study.Environment international · 2026Article
- Maternal PMReproductive toxicology (Elmsford, N.Y.) · 2026Article
- Mouse placentae generated by in vitro fertilization exhibit altered gene expression, activated hypoxia responses, and reduced fitness†.Biology of reproduction · 2026Article
- Article
- Relationship between exposure to air pollutants in the first trimester and spontaneous abortion in pregnant women in the river valley city.Scientific reports · 2024Article
- The association of short-term increases in ambient PM2.5 and temperature exposures with stillbirth: racial/ethnic disparities among Medicaid recipients.American journal of epidemiology · 2024Article
- Single-cell RNA sequencing reveals placental response under environmental stress.Nature communications · 2024Article
- Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms.BJOG : an international journal of obstetrics and gynaecology · 2024Review
- Short-term association between air pollution and daily genitourinary disorder admissions in Lanzhou, China.Environmental geochemistry and health · 2024Article
- Exploring the association between atmospheric pollutants and preterm birth risk in a river valley city.Frontiers in public health · 2024Article
- DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study.Clinical epigenetics · 2023Article
- Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology.Molecular and cellular endocrinology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. It maintains a critical balance between maternal and fetal homeostasis. Placental dysfunction can lead to adverse pregnancy outcomes including intra-uterine growth restriction, pre-eclampsia, or pre-term birth. Exposure to environmental pollutants contributes to the development of placental abnormalities, with poorly understood molecular underpinning. Here we used a mouse (C57BL/6) model of environmental pollutant exposure by administration of a particulate matter (SRM1649b at 300 μg/day/mouse) suspension intra-nasally beginning 2 months before conception and during gestation, in comparison to saline-exposed controls. Placental transcriptomes, at day 19 of gestation, were determined using bulk RNA-seq from whole placentas of exposed (n = 4) and control (n = 4) animals and scRNAseq of three distinct placental layers, followed by flow cytometry analysis of the placental immune cell landscape. Our results indicate a reduction in vascular placental cells, especially cells responsible for structural integrity, and increase in trophoblast proliferation in animals exposed to particulate matter. Pollution-induced inflammation was also evident, especially in the decidual layer. These data indicate that environmental exposure to air pollutants triggers changes in the placental cellular composition, mediating adverse pregnancy outcomes.
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Registered trials
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