Evidence map›Paper›PMID 35589725›Full record

ReviewNature reviews. Disease primers2022

Hypothyroidism.

Layal Chaker, Salman Razvi, Isabela M Bensenor, Fereidoun Azizi, Elizabeth N Pearce, Robin P Peeters

Erratum issuedOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 191 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 15 pooled it
39.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 15 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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  12. Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2023
    Pooled it
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  16. Trial
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  19. Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Layal ChakerDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Salman RazviTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-9047-1556
Isabela M BensenorCentro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Divisão de Clínica Médica, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-6723-5678
Fereidoun AziziEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Elizabeth N PearceSection of Endocrinology, Diabetes, Nutrition & Weight Management, Boston University School of Medicine, Boston, MA, USA.
Robin P PeetersDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands. r.peeters@erasmusmc.nl.
Boston University · USErasmus MC · NLHarvard University · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRNewcastle University · GBResearch Institute for Endocrine Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothyroidism is the common clinical condition of thyroid hormone deficiency and, if left untreated, can lead to serious adverse health effects on multiple organ systems, with the cardiovascular system as the most robustly studied target. Overt primary hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) concentration in combination with free thyroxine (fT

Indexed as

HypothyroidismIodineChildFemaleHumansPregnancyQuality of LifeThyrotropinThyroxineIodineThyrotropinThyroxine

Identifiers

PMID35589725
OpenAlexW4280515876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.