ArticleTranslational psychiatry2022
Altered hippocampus and amygdala subregion connectome hierarchy in major depressive disorder.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Postmortem evidence of decreased brain pH in major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- Electroconvulsive therapy induces rapid microstructural and macrostructural changes, but microstructural changes are longer-lasting.European archives of psychiatry and clinical neuroscience · 2026Trial
- Brain structural-functional connectivity coupling and glucose metabolism in adolescents with bipolar disorder and major depressive disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Universum Inspired Graph Contrast Learning for Major Depressive Disorder Identification: In Functional Brain Network View.CNS neuroscience & therapeutics · 2026Article
- Resting-state fMRI-based machine learning for predicting SSRI treatment response in major depressive disorder.BMC psychiatry · 2026Article
- Cellular and subcellular localization of the copper transporter CTR1 in human postmortem hippocampus and striatum.Scientific reports · 2026Article
- Sex-Based Mechanisms of Stress-Induced Alcohol-Seeking.Behavioral sciences (Basel, Switzerland) · 2026Article
- Hippocampal subfield-specific imaging in depression: the translational power of ultra-high field MRI.Translational psychiatry · 2026Review
- Resting-state EEG markers associated with violence risk in patients with major depressive disorder.Psychological medicine · 2026Article
- Shared molecular features and candidate pathways underlying gastric cancer-depression comorbidity: a systems biology analysis.Frontiers in bioinformatics · 2026Article
- Article
- Sex Differences in the Ventral Subiculum's Microcircuitry and Function.Hippocampus · 2026Review
- Functional network organization is locally atypical in children, adolescents, and young adults with congenital heart disease.NeuroImage. Clinical · 2026Article
- Regional activity within the human amygdala varies with season, mood and illuminance.Nature communications · 2025Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- Subchronic Intranasal Administration of NeuroEPO Reduces Long-Term Consequences of Severe Traumatic Brain Injury in Male Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Magnetic resonance imaging signatures of neuroinflammation in major depressive disorder with religious and spiritual problems.Scientific reports · 2025Article
- The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.Journal of neuroinflammation · 2025Review
- Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia: Insights from High-Resolution Magnetic Resonance Imaging.Medicina (Kaunas, Lithuania) · 2025Article
- Alteration of brain metabolism in lacunar stroke based onFrontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The hippocampus and amygdala limbic structures are critical to the etiology of major depressive disorder (MDD). However, there are no high-resolution characterizations of the role of their subregions in the whole brain network (connectome). Connectomic examination of these subregions can uncover disorder-related patterns that are otherwise missed when treated as single structures. 38 MDD patients and 40 healthy controls (HC) underwent anatomical and diffusion imaging using 7-Tesla MRI. Whole-brain segmentation was performed along with hippocampus and amygdala subregion segmentation, each representing a node in the connectome. Graph theory analysis was applied to examine the importance of the limbic subregions within the brain network using centrality features measured by node strength (sum of weights of the node's connections), Betweenness (number of shortest paths that traverse the node), and clustering coefficient (how connected the node's neighbors are to one another and forming a cluster). Compared to HC, MDD patients showed decreased node strength of the right hippocampus cornu ammonis (CA) 3/4, indicating decreased connectivity to the rest of the brain, and decreased clustering coefficient of the right dentate gyrus, implying it is less embedded in a cluster. Additionally, within the MDD group, the greater the embedding of the right amygdala central nucleus (CeA) in a cluster, the greater the severity of depressive symptoms. The altered role of these limbic subregions in the whole-brain connectome is related to diagnosis and depression severity, contributing to our understanding of the limbic system involvement in MDD and may elucidate the underlying mechanisms of depression.
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