Evidence map›Paper›PMID 35589452›Full record

ArticleVaccine2022

Factors associated with the intention to participate in COVID-19 vaccine clinical trials: A cross-sectional study in Peru.

Abraham De-Los-Rios-Pinto, Daniel Fernandez-Guzman, David R Soriano-Moreno, Lucero Sangster-Carrasco, Noelia Morocho-Alburqueque, Antony Pinedo-Soria, Valentina Murrieta-Ruiz, Angelica Diaz-Corrales, Jorge Alave, Wendy Nieto-Gutierrez and 1 more

Abstract read
In one paragraph

Article in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abraham De-Los-Rios-PintoEscuela Profesional de Medicina Humana, Universidad Nacional San Antonio Abad del Cusco, Cusco, Peru.
Daniel Fernandez-GuzmanEscuela Profesional de Medicina Humana, Universidad Nacional San Antonio Abad del Cusco, Cusco, Peru; Grupo Peruano de Investigación Epidemiológica, Unidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.
David R Soriano-MorenoUnidad de Investigación Clínica y Epidemiológica, Escuela de Medicina, Universidad Peruana Unión, Lima, Peru.
Lucero Sangster-CarrascoUniversidad Peruana de Ciencias Aplicadas, Facultad de Medicina, Lima, Peru.
Noelia Morocho-AlburquequeSociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Piura, Piura, Perú.
Antony Pinedo-SoriaFacultad de Medicina Humana, Universidad Nacional de San Martín, Tarapoto, Peru. Electronic address: apinedos@alumno.unsm.edu.pe.
Valentina Murrieta-RuizUniversidad Nacional de la Amazonía Peruana, Facultad de Medicina Humana Rafael Donayre Rojas, Iquitos, Loreto, Perú.
Angelica Diaz-CorralesUniversidad de San Martín de Porres, Facultad de Medicina Humana, Chiclayo, Lambayeque, Peru.
Jorge AlaveUniversidad Peruana Union, Escuela de Medicina Humana, Lima, Peru; Deparment of Medicine, Clinica Good Hope, Lima, Peru. Electronic address: jorgealave@upeu.edu.pe.
Wendy Nieto-GutierrezUnidad de Investigación para la Generación de Síntesis de Evidencia en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: wendy_nieto22@hotmail.com.
Jose Gonzales-ZamoraDivision of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peruvian American Medical Society, USA. Electronic address: jxg1416@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the factors associated with the intention to participate in COVID-19 vaccine clinical trials in the Peruvian population.

methodsCross-sectional study and secondary analysis of a database that involved Peruvian population during September 2020. The Poisson regression model was used to estimate the associated factors.

resultsData from 3231 individuals were analyzed, 44.1% of whom intended to participate in COVID-19 vaccine clinical trials. Factors associated with the outcome were being male (RPa: 1.25; 95% CI: 1.15-1.35), being from the highlands region (RPa: 1.18; 95% CI: 1.09-1.28) or jungle (RPa: 1.30; 95% CI: 1.15-1.47), having a relative that is a healthcare professional (PRa: 1.16; 95% CI: 1.06-1.28), using a medical source of information (PRa: 1.28; 95% CI: 1.17-1.41), and trusting in the possible effectiveness of vaccines (PRa: 1.40; 95% CI: 1.29-1.51). The main reason for not participating in the trial was the possibility of developing side effects (69.80%).

conclusionThere is an urgent need to generate a perception of safety in COVID-19 vaccine clinical trials, to increase the population's intention to participate in these studies, and to provide evidence-based information about the vaccine.

Indexed as

Clinical Trials as TopicCOVID-19 VaccinesIntentionPatient ParticipationCOVID-19Cross-Sectional StudiesFemaleHumansMalePeruCOVID-19 VaccinesAssociated factorsClinical TrialCoronavirusCOVID-19Intention to participateVaccine

Identifiers

PMID35589452
PMCPMC8986477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.