ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Early sleep after action observation plus motor imagery improves gait and balance abilities in older adults.Scientific reports · 2024Trial
- Early sleep after action observation and motor imagery training boosts improvements in manual dexterity.Scientific reports · 2023Trial
- Experience reorganizes content-specific memory traces in macaques.Nature neuroscience · 2026Article
- Motor Cortex VIP Interneurons Participate in Dexmedetomidine-Associated Sleep Modulation.Molecular neurobiology · 2026Article
- Article
- Implanted brain-computer interface functionality during nighttime in late-stage amyotrophic lateral sclerosis.Scientific reports · 2026Article
- Dream content and slow waves benefit prey against predator in a video game confrontation.Scientific reports · 2026Article
- Gesture encoding in human left precentral gyrus neuronal ensembles.Communications biology · 2025Article
- Stabilizing brain-computer interfaces through alignment of latent dynamics.Nature communications · 2025Article
- Article
- Song-like activation of syringeal and respiratory muscles during sleep in canaries.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Drawing promotes memory retention in a patient with sleep-related anterograde amnesia.Memory & cognition · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.PLoS biology · 2024Article
- Sleep Apnea and Amyotrophic Lateral Sclerosis: Cause, Correlation, Any Relation?Brain sciences · 2024Review
- Learning leaves a memory trace in motor cortex.Current biology : CB · 2024Article
- Motor cortex retains and reorients neural dynamics during motor imagery.Nature human behaviour · 2024Article
- Co-occurring ripple oscillations facilitate neuronal interactions between cortical locations in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neural reactivation during human sleep.Emerging topics in life sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Consolidation of memory is believed to involve offline replay of neural activity. While amply demonstrated in rodents, evidence for replay in humans, particularly regarding motor memory, is less compelling. To determine whether replay occurs after motor learning, we sought to record from motor cortex during a novel motor task and subsequent overnight sleep. A 36-year-old man with tetraplegia secondary to cervical spinal cord injury enrolled in the ongoing BrainGate brain-computer interface pilot clinical trial had two 96-channel intracortical microelectrode arrays placed chronically into left precentral gyrus. Single- and multi-unit activity was recorded while he played a color/sound sequence matching memory game. Intended movements were decoded from motor cortical neuronal activity by a real-time steady-state Kalman filter that allowed the participant to control a neurally driven cursor on the screen. Intracortical neural activity from precentral gyrus and 2-lead scalp EEG were recorded overnight as he slept. When decoded using the same steady-state Kalman filter parameters, intracortical neural signals recorded overnight replayed the target sequence from the memory game at intervals throughout at a frequency significantly greater than expected by chance. Replay events occurred at speeds ranging from 1 to 4 times as fast as initial task execution and were most frequently observed during slow-wave sleep. These results demonstrate that recent visuomotor skill acquisition in humans may be accompanied by replay of the corresponding motor cortex neural activity during sleep.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.