Evidence map›Paper›PMID 35589253›Full record

ReviewJournal of hepatology2022

"Beyond MELD" - Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation.

Jin Ge, W Ray Kim, Jennifer C Lai, Allison J Kwong

Abstract readReview
In one paragraph

Review in Journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. PRO AI: AI-augmented allocation is in our future-We should invest the necessary resources today.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Bone mineral density, sarcopenia and long-term survival in patients with cirrhosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article
  14. Prognosis algorithms for acute decompensation of cirrhosis and ACLF.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  15. Review
  16. Review
  17. Common definitions and variables are needed for the United States to join the conversation on acute-on-chronic liver failure.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jin GeDivision of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, CA, USA.
W Ray KimDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: wrkim@stanford.edu.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, CA, USA.
Allison J KwongDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
Stratification of Non-alcoholic Fatty Liver Disease using the SAFE ScoreR01DK127224 · NIDDK · STANFORD UNIVERSITY · PI KIM, W. RAY · 2020 to 2023
$1.7M
Defining Phenotypes of Alcohol-Associated Liver Disease with Acute Hepatic DecompensationK23AA029197 · NIAAA · STANFORD UNIVERSITY · PI KWONG, ALLISON · 2021 to 2025
$1.0M
NIAAA NIH HHS K23 AA029197NIA NIH HHS R01 AG059183NIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK127224
6 · The paper itself

Abstract

In this review article, we discuss the model for end-stage liver disease (MELD) score and its dual purpose in general and transplant hepatology. As the landscape of liver disease and transplantation has evolved considerably since the advent of the MELD score, we summarise emerging concepts, methodologies, and technologies that may improve mortality prognostication in the future. Finally, we explore how these novel concepts and technologies may be incorporated into clinical practice.

Indexed as

End Stage Liver DiseaseLiver TransplantationTissue and Organ ProcurementHumansSeverity of Illness IndexWaiting ListsAllocationClinical Decision SupportEHRFrailtyMELDOMOPPrognosticationSarcopenia

Identifiers

PMID35589253
PMCPMC10286631

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.