Evidence map›Paper›PMID 35588868›Full record

ArticleJournal of molecular biology2022

A Test and Refinement of Folding Free Energy Nearest Neighbor Parameters for RNA Including N

Marta Szabat, Martina Prochota, Ryszard Kierzek, Elzbieta Kierzek, David H Mathews

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Tailor made: the art of therapeutic mRNA design.Nature reviews. Drug discovery · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Marta SzabatInstitute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Martina ProchotaInstitute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Ryszard KierzekInstitute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Elzbieta KierzekInstitute of Bioorganic Chemistry Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland. Electronic address: elzbieta.kierzek@ibch.poznan.pl.
David H MathewsDepartment of Biochemistry & Biophysics and Center for RNA Biology, 601 Elmwood Avenue, Box 712, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, United States. Electronic address: david_mathews@urmc.rochester.edu.
Institute of Bioorganic Chemistry, Polish Academy of Sciences · PLUniversity of Rochester · US

Funding

Supporting RNAstructure: Software for RNA AnalysisR01GM076485 · NIGMS · UNIVERSITY OF ROCHESTER · PI MATHEWS, DAVID H. · 2006 to 2021
$4.7M
NIGMS NIH HHS R01 GM076485
6 · The paper itself

Abstract

RNA folding free energy change parameters are widely used to predict RNA secondary structure and to design RNA sequences. These parameters include terms for the folding free energies of helices and loops. Although the full set of parameters has only been traditionally available for the four common bases and backbone, it is well known that covalent modifications of nucleotides are widespread in natural RNAs. Covalent modifications are also widely used in engineered sequences. We recently derived a full set of nearest neighbor terms for RNA that includes N

Indexed as

AdenosineRNARNA FoldingEntropyAdenosineN-methyladenosineRNAoptical meltingRNA covalent modificationRNA folding stabilityRNA methylationRNA secondary structure prediction

Identifiers

PMID35588868
PMCPMC11235186
OpenAlexW4280499428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.